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MiR-124-3p alleviates the dezocine tolerance against pain by regulating TRAF6 in a rat model.

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收录情况： ◇ SCIE

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机构： [1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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关键词： dezocine tolerance miR-124-3p TRAF6

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MicroRNAs (miRNAs) play important roles in drug tolerance and regulating pain. The purpose of the present study is to explore the regulatory mechanism of miR-124-3p on dezocine tolerance against pain in a rat model. The expression of miR-124-3p and TRAF6 in spinal cord of rats was detected by quantitative reverse-transcription PCR. The paw withdrawal latency (PWL) and maximal potential efficiency % of rats were detected by PWL assay. The levels of IL-1β and TNF-α in spinal cord tissues of rats were measured by ELISA assay. The interaction between TRAF6 and miR-124-3p was predicted by TargetScan software (http://www.targetscan.org) and confirmed by the dual-luciferase reporter assay. The protein level of TRAF6 was determined by western blot. MiR-124-3p expression was highly downregulated in a dezocine-resistant model. MiR-124-3p overexpression could alleviate dezocine tolerance in rats. TRAF6 expression was significantly upregulated in a dezocine-resistant model. MiR-124-3p targeted TRAF6 and TRAF6 was negatively modulated by miR-124-3p. In addition, overexpression of TRAF6 could reverse the inhibitory effects of miR-124-3p on dezocine tolerance. Overexpression of miR-124-3p alleviates dezocine tolerance against pain via regulating TRAF6 in a rat model, providing a possible solution to address dezocine tolerance in clinical.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2021]版：

Q4 NEUROSCIENCES

最新[2024]版：

Q4 NEUROSCIENCES

影响因子： 1.7 最新[2024版] 1.5 最新五年平均 1.703 出版当年[2021版] 1.886 出版当年五年平均 1.837 出版前一年[2020版] 1.7 出版后一年[2022版]

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第一作者机构： [1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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通讯机构： [1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [*1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, Hebei Province 050011, China

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