机构：[1]Department of Oncology, Affiliated Xingtai People’s Hospital of Hebei Medical University, Xingtai, P.R. China[2]School of Artificial Intelligence, Hebei University of Technology, Tianjin, P.R. China[3]Department of Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China[4]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China河北医科大学第四医院整形外科临床科室[5]Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China
Clear cell renal cell carcinoma (ccRCC) is a common urological disease. Expression of the protein tyrosine phosphatase 12 gene (PTPN12) is decreased in many cancers; however, the relationship between PTPN12 gene function and renal cancer remains unclear.
We detected PTPN12 protein expression in ccRCC and corresponding normal tissues from 64 patients with ccRCC by immunohistochemistry, and relative PTPN12 mRNA levels by real-time quantitative polymerase chain reaction. The relationships between the relative expression levels of PTPN12 mRNA and the patients' clinical data were analyzed.
PTPN12 protein and mRNA expression levels were significantly lower in ccRCC compared with the corresponding normal tissues. The mRNA expression levels in the ccRCC and corresponding normal tissues from the 64 patients with ccRCC were 0.459±0.445 and 1.001±0.128, respectively, compared with the control (glyceraldehyde 3-phosphate dehydrogenase). There was a significant correlation between relative expression of PTPN12 mRNA in ccRCC tissues and tumor diameter and clinical stage.
The expression levels of PTPN12 protein and mRNA were significantly lower in ccRCC tissues compared with normal tissues. The role of PTPN12 may provide new insights and evidence to aid the diagnosis and targeted therapy of ccRCC.
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外文
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PubmedID：
中科院分区：
出版当年[2020]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2020]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Oncology, Affiliated Xingtai People’s Hospital of Hebei Medical University, Xingtai, P.R. China
通讯作者：
通讯机构：[4]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China[*1]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R. China.
推荐引用方式(GB/T 7714)：
Jin Yi,Wang Tian-Xi,Li Hao,et al.Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma.[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(12):doi:10.1177/0300060520936041.
APA：
Jin Yi,Wang Tian-Xi,Li Hao,Guo Peng&Wang Qing-Qing.(2020).Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma..JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(12)
MLA：
Jin Yi,et al."Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma.".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..12(2020)
