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Quantitative proteomics and phosphoproteomic analyses of mouse livers after tick-borne Babesia microti infection.

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机构： [1]Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China [2]Instrumental Analysis Center, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China [3]The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, PR China [4]Department of Pathogenic Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, PR China

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关键词： Babesia microti Liver Phosphorylation Quantitative proteomics Lipid metabolism

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Babesia microti is a tick-borne protozoan parasite that infects the red blood cells of mice, humans, and other mammals. The liver tissues of BALB/c mice infected with B. microti exhibit severe injury. To further investigate the molecular mechanisms underlying liver injury and liver self-repair after B. microti infection, data-independent acquisition (DIA) quantitative proteomics was used to analyse changes in the expression and phosphorylation of proteins in liver tissues of BALB/c mice during a B. microti infection period and a recovery period. The expression of FABP1 and ACBP, which are related to fatty acid transport in the liver, was downregulated after infection with B. microti, as was the expression of Acox1, Ehhadh and Acaa1a, which are crucial rate-limiting enzymes in the process of fatty acid β oxidation. The phosphorylation levels of AMP-activated protein kinase (AMPK) and Hormone-sensitive lipase (HSL) were also downregulated. In addition, the expression of PSMB9, CTSC, and other immune-related proteins was increased, reflecting an active immune regulation mechanism in the mice. The weights of mice infected with B. microti were significantly reduced, and the phosphorylation levels of IRS-1, c-Raf, mTOR, and other proteins related to growth and development were downregulated. Copyright © 2020 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 2 区寄生虫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区寄生虫学

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出版当年[2021]版：

Q1 PARASITOLOGY

最新[2023]版：

Q1 PARASITOLOGY

影响因子： 3.7 最新[2023版] 3.5 最新五年平均 4.33 出版当年[2021版] 4.388 出版当年五年平均 3.981 出版前一年[2020版] 4 出版后一年[2022版]

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第一作者机构： [1]Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China [2]Instrumental Analysis Center, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China

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