个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Luo Yixiao[1,2] * ; Zhao Penghui[2] * ; Dou Mengxiao[2] ; Mao Jiawen[2] ; Zhang Ge[2] ; Su Yujiao[2] ; Wang Qingqun[2] ; Wang Qian[2] ; Wang Yurun[2] ; Sun Ruoxuan[2] ; Liu Tingxuan[2] ; Gong Miao[2,4] ; Gao Yuan[2,4,5] ; Yin Xi[2,3,*2] ; Song Li[2,4,5,*1] ; Shi Haishui[2,4,5,6,*1] ;
机构： [1]Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China [2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [3]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China [4]Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, 050017, China [5]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University, Shijiazhuang, 050017, China [6]Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology. Chinese Academy of Medical Sciences, Shijiazhuang, 050017, China
出处：
DOI： 10.1016/j.neuropharm.2021.108563
ISSN：

关键词： Microbiota Trimethylamine N-Oxide Social dominance Sexual preference Hippocampus Metabolomics analysis

摘要：
Increasing evidence indicates that gut microbiota and its metabolites can influence the brain function and the related behaviors. Trimethylamine N-oxide (TMAO), an indirect metabolite of gut microbiota, has been linked to aging, cognitive impairment, and many brain disorders. However, the potential effects of TMAO on social behaviors remain elusive. The present study investigated the effects of early life systemic TMAO exposure and intra-hippocampal TMAO infusion during adulthood on social behaviors in mice. We also analyzed the effects of intra-hippocampus infusion of TMAO during adulthood on levels of metabolites. The results showed that both systemic TMAO exposure in the post-weaning period and intra-hippocampal TMAO infusion during adulthood decreased social rank and reduced sexual preference in adult mice. Data from LC-MS metabolomics analysis showed that intra-hippocampal TMAO infusion induced a total 207 differential metabolites, which belongs to several metabolic or signaling pathways, especially FoxO signaling pathway and retrograde endocannabinoid signaling pathway. These data suggest that TMAO may affect social behaviors by regulating metabolites in the hippocampus, which may provide a new insight into the role of gut microbiota in regulating social behaviors. Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (81771462, 81771434), Natural Science Foundation of Hebei Province (H2018206119, SLRC2019047), Foundation from Educational Commission of Hebei Province of China (ZD2019059), CAMS Innovation Fund for Medical Sciences (2019-I2M-5-055), and Special Foundation for Excellent Undergraduate Students from Hebei Medical University (USIP2020016).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 神经科学 2 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药学 3 区 神经科学
JCR分区：
出版当年[2021]版：
Q1 PHARMACOLOGY & PHARMACY Q2 NEUROSCIENCES
最新[2023]版：
Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China [2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China
共同第一作者：
通讯作者：
通讯机构： [2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [3]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China [4]Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, 050017, China [5]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University, Shijiazhuang, 050017, China [6]Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology. Chinese Academy of Medical Sciences, Shijiazhuang, 050017, China [*1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China. [*2]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
推荐引用方式(GB/T 7714)：
Luo Yixiao,Zhao Penghui,Dou Mengxiao,et al.Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation.[J].NEUROPHARMACOLOGY.2021,191:doi:10.1016/j.neuropharm.2021.108563.
APA：
Luo Yixiao,Zhao Penghui,Dou Mengxiao,Mao Jiawen,Zhang Ge...&Shi Haishui.(2021).Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation..NEUROPHARMACOLOGY,191,
MLA：
Luo Yixiao,et al."Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation.".NEUROPHARMACOLOGY 191.(2021)

相关文献

[1]Postweaning sodium citrate exposure induces long-lasting and sex-dependent effects on social behaviours in mice [2]Effects of chronic triclosan exposure on social behaviors in adult mice. [3]Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction [4]Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia [5]Long-lasting effects of postweaning sodium butyrate exposure on social behaviors in adult mice. [6]Prediction and analysis of the tumor invasiveness of pulmonary ground-glass nodules based on metabolomics [7]Integrated proteomics and metabolomics analysis reveals hubs protein and network alterations in myasthenia gravis [8]Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve [9]孕期低水平铅暴露对子代大鼠海马神经生长相关蛋白表达的影响 [10]Causal Associations of Gut Microbiota Species With Lymphoma: A Two-Sample Mendelian Randomization Study

资源点击量：39770 今日访问量：0 总访问量：1333 更新日期：2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 河北医科大学第四医院 技术支持：重庆聚合科技有限公司 地址：河北省石家庄市健康路12号