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Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy

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Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

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DOI：

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关键词： Sepsis-associated encephalopathy METTL3 hippocampal neurons m6A GOT1 SAE

摘要：

This study explores the mechanism of methyltransferase like 3 (METTL3) on sepsis-associated encephalopathy (SAE)-induced hippocampal neuronal injury.A murine model of SAE was established by caecal ligation and puncture. Hippocampal cells were induced by lipopolysaccharide (LPS). The mouse survival was observed and behavioural tests evaluated cognitive function. METTL3 and glutamic-oxaloacetic transaminase 1 (GOT1) expressions were detected via RT-qPCR and Western blot. Immunofluorescence staining examined the co-localization of NeuN and METTL3. The m6A enrichment on GOT1 was determined by MeRIP.METTL3 and GOT1 were highly expressed in SAE mice and LPS-stimulated hippocampal cells. SAE mice exhibited cognitive function impairment, reduced survival rate, and decreased neuronal cells. LPS induction increased hippocampal cell apoptosis and enhanced inflammation. Silence of METTL3 reduced hippocampal neuronal injury in SAE mice and LPS-induced hippocampal cell injury.METTL3-mediated m6A modification on GOT1 mRNA elevates GOT1 expression, thereby aggravating SAE-induced hippocampal neuronal injury.

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中科院分区：

出版当年[2025]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢 4 区生理学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢 4 区生理学

JCR分区：

出版当年[2023]版：

Q2 PHYSIOLOGY Q3 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q2 PHYSIOLOGY Q3 ENDOCRINOLOGY & METABOLISM

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.5 出版当年[2025版] 2.7 出版当年五年平均 0 出版前一年[2024版]

第一作者：

第一作者机构： [1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

通讯作者：

通讯机构： [1]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

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