详情页

当前位置：首页 > 详情页

Clinical characteristics and treatment evaluation of diffuse large B-cell lymphoma in Chinese children and adolescents: a multicenter clinical study of China-Net childhood lymphoma group B-NHL-2017

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Hematology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, 201102, China. [2]Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China. [3]Department of Pediatric Lymphoma, Beijing Gobroad Boren Hospital, Beijing, 100070, China. [4]Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100039, China. [5]Department of Hematology and Oncology, Hunan Children's Hospital, Changsha, 410007, China. [6]Department of Pediatrics, Shandong Provincial Hospital, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. [7]Department of Hematology and Oncology, National Children's Regional Medical Center (Northwest), The Affiliated Children Hospital of Xi'an Jiaotong University, Xi'an Children's Hospital, Xi'an, 710002, China. [8]Department of Hematology and Oncology, Beijing Children's Hospital, National Children's Regional Medical Center, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou Hospital, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, 450012, China. [9]Department of Pediatrics, Peking University People's Hospital, Beijing, 100044, China. [10]Department of Hematology and Oncology, Jinan Children's Hospital, Children's Hospital Affiliated to Shandong University, Jinan, 250022, China. [11]Department of Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, 050004, China. [12]Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China. [13]Department of Pediatric Hematology and Oncology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China. [14]Department of Hematology, Capital Institute of Pediatrics, Children's Hospital, Capital Institute of Pediatrics, Beijing, 100020, China. [15]Department of Pediatric Hematology and Oncology, Northwest Women's and Children's Hospital, Shaanxi Maternal and Child Health Hospital, Xi'an, 710061, China. [16]Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [17]Department of Pediatrics, Quanzhou First Hospital, Fujian Medical University, Fujian, Quanzhou, 362002, China. [18]Department of Pediatrics, Hebei Tumor Hospital, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China. [19]Department of Hematology and Oncology, Children's Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. [20]Department of Pediatric Hematology, The Second Affiliated Hospital of Wenzhou Medical University, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. [21]Department of Hematology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, 201102, China [22]Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China. [23]Department of Pediatric Lymphoma, Beijing Gobroad Boren Hospital, Beijing, 100070, China. [24]Department of Hematology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, 201102, China

出处：

DOI：

ISSN：

关键词： Diffuse large B-cell lymphoma Child Treatment Chemotherapy Prognosis

摘要：

China-Net Childhood Lymphoma (CNCL) group B-NHL-2017 study is a prospective multi-center study in China, with the purpose of standardizing the diagnosis and treatment of childhood lymphoma, and improving the prognosis.From May 2017 to June 2023, 20 centers participated in the diffuse large B-cell lymphoma (DLBCL) study. The clinical data were analyzed to summarize the clinical characteristics, treatment response and outcome. The primary endpoint was 5-year event-free survival (EFS). The trial is registered with the Chinese Clinical Trial Registry (ChiCTR1800020067).A total of 138 children and adolescents were enrolled, including 101 males and 37 females. The median age of disease diagnosis was 9.0 years (range: 2.3-15.5 years). The range of follow-up time was 17 d-6.0 years. A total of 12 events occurred in this study, including 7 deaths. of which 4 patients died of disease and chemotherapy comorbidities (severe infection, septic shock, etc.), 1 died of disease progression (enlargement of the primary tumor and tumor metastasis), 1 died of recurrence, and 1 died of severe pneumonia in the third year after completing all chemotherapy courses. Recurrence occurred in 6 (4.3%) patients at 14.9 months (range: 4.4-32.6 months) after initial treatment. The 5-year overall survival (OS) was 90.7 ± 5.0% and the 5-year EFS was 85.5 ± 5.4%. Based on Cox regression analysis, no Rituximab during treatment is an independent risk factor for mortality in patients with DLBCL.The efficacy of CNCL-B-NHL-2017 protocol in the treatment of DLBCL in children and adolescents is close to results of international studies.© 2025. The Author(s).

基金：

语种：

PubmedID：

中科院分区：

出版当年[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

第一作者：

第一作者机构： [1]Department of Hematology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, 201102, China.

共同第一作者：

通讯作者：

通讯机构： [22]Medical Oncology Department, Pediatric Oncology Center, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China. [23]Department of Pediatric Lymphoma, Beijing Gobroad Boren Hospital, Beijing, 100070, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Clinical characteristics and treatment evaluation of diffuse large B-cell lymphoma in Chinese children and adolescents: a multicenter clinical study of China-Net childhood lymphoma group B-NHL-2017

文献详情

相关文献