机构：[1]Geriatric Department, Shenzhen People’s Hospital, TheSecond Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Scienceand Technology, Shenzhen, Guangdong, China深圳市康宁医院深圳市人民医院深圳医学信息中心中国医科大学附属盛京医院[2]School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang, Hebei, China[3]School of Basic Medicine, Peking University,Beijing, China[4]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China河北医科大学第四医院[5]Anesthesiology Department, Beijing Hospital, National Center of Gerontology, Dong Dan, Beijing, China[6]Epidemiology Department, Beijing Hospital, NationalCenter of Gerontology, Dong Dan, Beijing, China[7]Department of Urinary Surgery, The Fourth Hospital ofHebei Medical University, Shijiazhuang, Hebei, China临床科室泌尿外科河北医科大学第四医院
Objective Use of a catheter lock solution plays a decisive role in vascular access. The effects of different concentrations of heparin and different types of catheter lock solutions are controversial. Therefore, this study aimed to compare the efficacy and safety of sodium citrate and sodium heparin catheter lock solutions. Methods A total of 120 patients were divided into four groups (30 patients per group) according to the use of catheter lock solution as follows: 6250 U/mL sodium heparin, 5000 U/mL sodium heparin, 2500 U/mL sodium heparin, and 4% sodium citrate. Coagulation function and the incidence of catheter occlusion, hemorrhage, and catheter-related infections were recorded. Results The different catheter lock solutions were significantly related to conduit blockage, hemorrhage, infection, and leakage levels. In the 4% sodium citrate group, the odds ratio was 0.688 for conduit blockage (95% confidence interval [CI], 0.206-2.297), 0.286 for hemorrhage (95% CI, 0.091-0.899), 0.266 for infection (95% CI, 0.073-0.964), and 0.416 for leakage (95% CI, 0.141-1.225) compared with the 6250 U/mL sodium heparin. Conclusions The solution 4% sodium citrate can effectively reduce the risk of catheter obstruction, bleeding, infection, and leakage better than sodium heparin in patients with long-term intravenous indwelling catheters.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2019]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
最新[2024]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Geriatric Department, Shenzhen People’s Hospital, TheSecond Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Scienceand Technology, Shenzhen, Guangdong, China
通讯作者：
通讯机构：[7]Department of Urinary Surgery, The Fourth Hospital ofHebei Medical University, Shijiazhuang, Hebei, China[*1]Department of Urinary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.
推荐引用方式(GB/T 7714)：
Huang He-ming,Jiang Xin,Meng Ling-bing,et al.Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2019,47(9):4204-4214.doi:10.1177/0300060519859143.
APA：
Huang, He-ming,Jiang, Xin,Meng, Ling-bing,Di, Chen-yi,Guo, Peng...&Shi, Chang-jin.(2019).Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,47,(9)
MLA：
Huang, He-ming,et al."Reducing catheter-associated complications using 4% sodium citrate versus sodium heparin as a catheter lock solution".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 47..9(2019):4204-4214
