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Molecular fingerprint of precancerous lesions in breast atypical hyperplasia(Open Access)

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收录情况： ◇ SCIE

作者：
Chao Zheng[1] * ; Hong Ying Jia[2] ; Li Yuan Liu[1] ; Qi Wang[3] ; Hong Chuan Jiang[4] ; Li Song Teng [5] ; Cui Zhi Geng[6] ; Feng Jin[7] ; Li Li Tang[8] ; Jian Guo Zhang[9] ; Xiang Wang[10] ; Shu Wang[11] ; Fernandez-Escobar Alejandro[12] ; Fei Wang[1] ; Li Xiang Yu[1] ; Fei Zhou[1] ; Yu Juan Xiang[1] ; Shu Ya Huang[1] ; Qin Ye Fu[1] ; Qiang Zhang[1] ; De Zong Gao[1] ; Zhong Bing Ma[1] ; Liang Li[1] ; Zhi Min Fan[13] ; Zhi Gang Yu[1,*1] ;
机构： [1]Department of Breast Surgery, The Second Hospital,Cheeloo College of Medicine, Shandong University, Jinan,Shandong, China [2]Center of Evidence-based Medicine, The SecondHospital, Cheeloo College of Medicine, ShandongUniversity, Jinan, Shandong, China [3]Breast Disease Center, Guangdong Maternal and ChildHealth Care Hospital, Guangzhou, Guangdong, China [4]Department of General Surgery, Beijing ChaoyangHospital, Beijing, China [5]Department of Oncology Surgery, The First AffiliatedHospital of Zhejiang University, Hangzhou, Zhejiang, China [6]Breast Center, the Fourth Hospital of Hebei MedicalUniversity, Shijiazhuang, Hebei, China [7]Department of Breast Surgery, the First AffiliatedHospital of China Medical University, Shenyang, Liaoning,China [8]Department of Breast Surgery, Xiangya Hospital ofCentral South University, Changsha, Hunan, China [9]Department of General Surgery, the Second AffiliatedHospital of Harbin Medical University, Harbin,Heilongjiang, China [10]Department of Breast Surgery, Cancer Hospital,Chinese Academy of Medical Sciences, Beijing, China [11]Breast Disease Center, Peking University People’sHospital, Beijing, China [12]Translational Research Program, University of Toronto,Toronto, Ontario, Canada [13]Department of Breast Surgery, the First Hospital of JilinUniversity, Changchun, Jilin, China
出处：
DOI： 10.1177/0300060520931616
ISSN：

关键词： atypical hyperplasia Breast cancer early diagnosis molecular fingerprint Raman spectroscopy shell-isolated nanoparticle

摘要：
Objective: To identify atypical hyperplasia (AH) of the breast by shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS), and to explore the molecular fingerprinting characteristics of breast AH. Methods: Breast hyperplasia was studied in 11 hospitals across China from January 2015 to December 2016. All patients completed questionnaires on women’s health. The differences between patients with and without breast AH were compared. AH breast lesions were detected by Raman spectroscopy followed by the SHINERS technique. Results: There were no significant differences in clinical features and risk-related factors between patients with breast AH (n = 37) and the control group (n = 2576). Fifteen cases of breast AH lesions were detected by Raman spectroscopy. The main different Raman peaks in patients with AH appeared at 880, 1001, 1086, 1156, 1260, and 1610 cm−1, attributed to the different vibrational modes of nucleic acids, β-carotene, and proteins. Shell-isolated nanoparticles had different enhancement effects on the nucleic acid, protein, and lipid components in AH. Conclusion: Raman spectroscopy can detect characteristic molecular changes in breast AH lesions, and may thus be useful for the non-invasive early diagnosis and for investigating the mechanism of tumorigenesis in patients with breast AH. © The Author(s) 2020.

基金：
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Health and Family Planning Commission’s Public-Benefit Project [grant no. 201502027], and the National Natural Science Foundation of China [NSFC grant no. 81702603], the Key Project of the Natural Science Foundation of Shandong Province [grant no. ZR2014HZ004], the Shandong Medical and Health Technology Development Plan Project [grant no. 2015WS0309], the Natural Science Foundation of Shandong Province [grant no. ZR2014HL074], and the Natural Science Foundation of Shandong Province [grant no. 2015ZRE27471].
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出版当年[2020]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 药学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 药学
JCR分区：
出版当年[2020]版：
Q4 PHARMACOLOGY & PHARMACY Q4 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4 MEDICINE, RESEARCH & EXPERIMENTAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Breast Surgery, The Second Hospital,Cheeloo College of Medicine, Shandong University, Jinan,Shandong, China
通讯作者：
通讯机构： [1]Department of Breast Surgery, The Second Hospital,Cheeloo College of Medicine, Shandong University, Jinan,Shandong, China [*1]Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, China
推荐引用方式(GB/T 7714)：
Chao Zheng,Hong Ying Jia,Li Yuan Liu,et al.Molecular fingerprint of precancerous lesions in breast atypical hyperplasia(Open Access)[J].Journal Of International Medical Research.2020,48(6):300060520931616.doi:10.1177/0300060520931616.
APA：
Chao Zheng,Hong Ying Jia,Li Yuan Liu,Qi Wang,Hong Chuan Jiang...&Zhi Gang Yu.(2020).Molecular fingerprint of precancerous lesions in breast atypical hyperplasia(Open Access).Journal Of International Medical Research,48,(6)
MLA：
Chao Zheng,et al."Molecular fingerprint of precancerous lesions in breast atypical hyperplasia(Open Access)".Journal Of International Medical Research 48..6(2020):300060520931616

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