Background: The aim of this study was to investigate the association between body mass index (BMI) and prognosis of Chinese women with breast cancer. Patients and Methods: 3,380 primary breast cancer patients who underwent surgery from 2010 to 2012 were selected and classified as low BMI group (BMI < 25.0) and high BMI group (BMI >= 25.0). The follow-up data for disease-free survival (DFS) and overall survival (OS) were obtained from 3,178 patients (median followup of 58 months). Cox regression analysis was used to evaluate the effect of BMI on DFS and OS. Results: The high BMI group showed more aggressive pathological features. BMI was negatively associated with OS (hazard ratio (HR) 1.33, 95% confidence interval (CI) 1.06-1.66; p = 0.012) but not DFS (HR 1.15, 95% CI 0.94-1.40; p = 0.17). Furthermore, when stratified by age, BMI was significantly and negatively associated with OS (HR 1.43, 95% CI 1.05-1.95; p = 0.025) in patients above 50 years of age, but this effect was not detected in younger patients. Conclusion: BMI was an independent prognostic factor of OS in Chinese women with breast cancer, and age might be a mitigating factor. Among patients above 50 years of age, those with a high BMI were at greater risk of poor prognosis compared to individuals with a low BMI. (c) 2019 S. Karger AG, Basel
第一作者机构：[1]Hebei Med Univ, Hosp 4, Breast Ctr, 169 Tianshan St, Shijiazhuang 050035, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 4, Breast Ctr, 169 Tianshan St, Shijiazhuang 050035, Hebei, Peoples R China[*1]Breast Center, Fourth Hospital of Hebei Medical University No. 169 Tianshan Street Shijiazhuang, 050035 (China)
推荐引用方式(GB/T 7714)：
Wang Xue,Hui Tian-Li,Wang Mei-Qi,et al.Body Mass Index at Diagnosis as a Prognostic Factor for Early-Stage Invasive Breast Cancer after Surgical Resection[J].ONCOLOGY RESEARCH AND TREATMENT.2019,42(4):190-196.doi:10.1159/000496548.
APA：
Wang, Xue,Hui, Tian-Li,Wang, Mei-Qi,Liu, Huan,Li, Ruo-Yang&Song, Zhen-Chuan.(2019).Body Mass Index at Diagnosis as a Prognostic Factor for Early-Stage Invasive Breast Cancer after Surgical Resection.ONCOLOGY RESEARCH AND TREATMENT,42,(4)
MLA：
Wang, Xue,et al."Body Mass Index at Diagnosis as a Prognostic Factor for Early-Stage Invasive Breast Cancer after Surgical Resection".ONCOLOGY RESEARCH AND TREATMENT 42..4(2019):190-196
