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Distinct effects of body mass index and waist/hip ratio on risk of breast cancer by joint estrogen and progestogen receptor status: Results from a case-control study in northern and eastern China and implications for chemoprevention(Open Access)

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收录情况： ◇ SCIE

作者：
Wang, F[a] * ; Liu, L[a] ; Cui, S[b] ; Tian, F[c] ; Fan, Z[d] ; Geng, C[e] ; Cao, X[f] ; Yang, Z[g] ; Wang, X[h] ; Liang, H[i] ; Wang, S[j] ; Jiang, H[k] ; Duan, X[l] ; Wang, H[m] ; Li, G[n] ; Wang, Q[o] ; Zhang, J[p] ; Jin, F[q] ; Tang, J[r] ; Li, L[s] ; Zhu, S[t] ; Zuo, W[u] ; Ma, Z[a] ; Zhou, F[a] ; Yu, L[a] ; Xiang, Y[a] ; Li, L[a] ; Shen, S[a] ; Yu, Z[a,v,*1] ;
机构： [a]Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong Province, China [b]Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan Province, China [c]Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi Province, China [d]Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China [e]Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China [f]Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China [g]Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong Province, China [h]Department of Breast Surgery, Chinese Academy of Medical Sciences, Cancer Hospital, Beijing, China [i]Department of General Surgery, Linyi People’s Hospital, Linyi, Shandong Province, China [j]Breast Disease Center, Peking University People’s Hospital, Beijing, China [k]Department of General Surgery, Beijing Chaoyang Hospital, Beijing, China [l]Breast Disease Center, Peking University First Hospital, Beijing, China [m]Breast Center, Qingdao University Affiliated Hospital, Qingdao, Shandong Province, China [n]Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong Province, China [o]Department of Breast Surgery, The Second Affiliated Hospital of Qingdao Medical College, Qingdao Central Hospital, Qingdao, Shandong Province, China [p]Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China [q]Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China [r]Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu Province, China [s]Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong Province, China [t]Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China [u]Breast Cancer Center, Shandong Cancer Hospital, Jinan, Shandong Province, China [v]Suzhou Institute of Shandong University, Suzhou, Jiangsu Province, China
出处：
DOI： 10.1634/theoncologist.2017-0148
ISSN：

关键词： Body mass index Breast neoplasms Estrogen receptors Progesterone receptors Waist/hip ratio

摘要：
Background. Obesity is a consideration in the pharmacologic intervention for estrogen receptor (ER) positive (ER+) breast cancer risk. Body mass index (BMI) and waist/hip ratio (WHR) have demonstrated different effects on breast cancer risk in relation to estrogen receptor (ER) status, but the results have been inconsistent. Furthermore, the situation in Chinese women remains unclear. Materials and Methods. We conducted a case-control study including 1,439 breast cancer cases in Northern and Eastern China. Both ER and progesterone receptor (PR) statuses were available for 1,316 cases. Associations between body size-related factors and breast cancer risk defined by receptor status were assessed by multiple polytomous unconditional logistic regression analysis. Results. Body mass index and WHR were positively associated with overall breast cancer risk. Body mass index was positively associated with both ER+/PR positive (PR+) and ER negative (ER-)/PR negative(PR-) subtype risks, although only significantly for ER+/PR+ subtype. Waist–hip ratio was only positively correlated with ER-/PR- subtype risk, although independent of BMI. Body mass index was positively associated with risk of ER+/PR+ and ER-/PR- subtypes in premenopausal women, whereas WHR was inversely correlated with ER+/PR- and positively with ER-/PR- subtype risks. Among postmenopausal women, WHR >0.85 was associated with increased risk of ER-/PR- subtype. Conclusion. Both general and central obesity contribute to breast cancer risk, with different effects on specific subtypes. General obesity, indicated by BMI, is more strongly associated with ER+/PR+ subtype, especially among premenopausal women, whereas central obesity, indicated by WHR, is more specific for ER-/PR- subtype, independent of menopausal status. These results suggest that different chemoprevention strategies may be appropriate in selected individuals. © 2017 The Authors.

基金：
This research was funded by a Hospital Clinical Key Project of the Ministry of Health of the People’s Republic of China (Establishment and Improvement of High-Risk Populations Screening and Evaluation System for Breast Cancer), the Science and Technology Plan Projects of Jiangsu Province (BL2014055), and a Youth Foundation of the Second Hospital of Shandong University (Y2013010039). We thank all the individuals involved in this case-control study for their participation.
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外文
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中科院分区：
出版当年[2017]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2017]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong Province, China
通讯作者：
通讯机构： [a]Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong Province, China [v]Suzhou Institute of Shandong University, Suzhou, Jiangsu Province, China [*1]Department of Breast Surgery, the Second Hospital of Shandong University, 247 Beiyuan St, Jinan, Shandong Province 250033, People’s Republic of China
推荐引用方式(GB/T 7714)：
Wang F,Liu L,Cui S,et al.Distinct effects of body mass index and waist/hip ratio on risk of breast cancer by joint estrogen and progestogen receptor status: Results from a case-control study in northern and eastern China and implications for chemoprevention(Open Access)[J].ONCOLOGIST.2017,22(12):1431-1443.doi:10.1634/theoncologist.2017-0148.
APA：
Wang, F,Liu, L,Cui, S,Tian, F,Fan, Z...&Yu, Z.(2017).Distinct effects of body mass index and waist/hip ratio on risk of breast cancer by joint estrogen and progestogen receptor status: Results from a case-control study in northern and eastern China and implications for chemoprevention(Open Access).ONCOLOGIST,22,(12)
MLA：
Wang, F,et al."Distinct effects of body mass index and waist/hip ratio on risk of breast cancer by joint estrogen and progestogen receptor status: Results from a case-control study in northern and eastern China and implications for chemoprevention(Open Access)".ONCOLOGIST 22..12(2017):1431-1443

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