机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, China[3]Center of Stroke,Beijing Institute for Brain Disorders, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
Background and Purpose- The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk of recurrent stroke among patients with minor stroke and transient ischemic attack. We aimed to determine whether the efficacy of clopidogrel-aspirin therapy among patients with minor stroke / transient ischemic attack was influenced by the stratification of CYP2C19 genotype and body mass index (BMI). Methods- CYP2C19 loss-of-function allele (LoFA) carriers were defined as patients with either LoFA of *2 or *3. Low/normal weight and overweight/obesity was defined as BMI <25 and >= 25 kg/m(2), respectively. Primary outcome was defined as stroke recurrence at 3 months. Results- In a total of 2933 patients, there were 1726 (58.8%) LoFA carriers and 1275 (43.5%) patients with overweight/obesity (BMI >= 25 kg/m(2)). Stratified analyses by LoFA carrying status and BMI, hazard ratios (hazard ratios 95% CIs) of the clopidogrel-aspirin therapy for stroke recurrence were 0.90 (0.60-1.36), 0.87 (0.56-1.35), 0.65 (0.39-1.09), and 0.40 (0.22-0.71) among subgroups of LoFA carriers with overweight/obesity, LoFA carriers with low/normal weight, LoFA noncarriers with overweight/obesity, and LoFA noncarriers with low/normal weight, respectively, with P=0.049 for interaction. Conclusions- Efficacy of clopidogrel-aspirin therapy in reducing the risk of stroke recurrence is not present in CYP2C19 LoFA noncarriers with overweight/obesity. Our study suggests that BMI significantly influences the correlation between CYP2C19 genotype and efficacy of clopidogrel-aspirin therapy.
基金：
This work was supported by the Ministry of Science and Technology
of The People’s Republic of China (2016YFC0901001/2016YFC0
901002/2017YFC1310901); National Natural Science Foundation
of China (81701141); Young Scientist Program [YSP201704] and
Young Elite Scientists Sponsorship Program by China Association
for Science and Technology [2018QNRC001].
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China[2]China National Clinical Research Center for Neurological Diseases, Beijing, China[3]Center of Stroke,Beijing Institute for Brain Disorders, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China[2]China National Clinical Research Center for Neurological Diseases, Beijing, China[3]Center of Stroke,Beijing Institute for Brain Disorders, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China[*1]No. 119 S 4th Ring W Rd, Fengtai District, Beijing, China 100070.
推荐引用方式(GB/T 7714)：
Jinglin Mo,Zimo Chen,Jie Xu,et al.Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity[J].STROKE.2020,51(1):224-231.doi:10.1161/STROKEAHA.119.026845.
APA：
Jinglin Mo,Zimo Chen,Jie Xu,Anxin Wang,Liye Dai...&the CHANCE Investigators.(2020).Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity.STROKE,51,(1)
MLA：
Jinglin Mo,et al."Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity".STROKE 51..1(2020):224-231
医学