Objectives A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with liposarcoma by examining associations between their expression levels and clinical outcomes. Methods Clinical and histopathological characteristics and follow-up and survival information were retrospectively reviewed for 42 liposarcoma cases. Sirtuin-1 and VEGF protein expression levels were evaluated by immunohistochemistry and their associations with clinical parameters were analyzed using the Spearman-rho test. Univariate and multivariate Cox regression analyses were performed to identify potential prognostic factors. Kaplan-Meier analysis was performed to analyze overall survival. Results Sirtuin-1 and VEGF protein expression levels were significantly associated with histological grade, metastasis, and American Joint Committee on Cancer stage. A significant positive correlation was observed between sirtuin-1 and VEGF expression levels (R = 0.677). In univariate analysis, sirtuin-1 and VEGF expression were correlated with shorter overall survival, but the association was significant only for sirtuin-1 (hazard ratio = 3.752, 95% confidence interval 1.553-9.062) in multivariate analysis. Conclusion Sirtuin-1 and VEGF expression levels are significantly correlated with progression of liposarcoma, and sirtuin-1 expression significantly predicts a poor prognosis in patients with liposarcoma.
基金：
Key Project of Medical-Science Research of Hebei Province [20180564]; Natural Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [H2019206309]
第一作者机构：[1]Hebei Med Univ, Dept Orthoped, Hosp 4, 12 Hlth Rd, Shijiazhuang 050011, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Med Univ, Dept Orthoped, Hosp 4, 12 Hlth Rd, Shijiazhuang 050011, Hebei, Peoples R China[*1]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, P. R. China.
推荐引用方式(GB/T 7714)：
Wu Hongzeng,Zhang Qianqian,Zhao Yi,et al.Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(6):doi:10.1177/0300060520926355.
APA：
Wu, Hongzeng,Zhang, Qianqian,Zhao, Yi,Xu, Fengzhou,Zhang, Jinming...&Feng, Helin.(2020).Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(6)
MLA：
Wu, Hongzeng,et al."Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..6(2020)
