详情页

当前位置：首页 > 详情页

Synthesis and antiproliferative activity of novel 4-azasteroidal-17-hydrazone derivatives

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]College of Science, Hebei University of Science and Technology, Shijiazhuang, P.R. China [2]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China

出处：

DOI：

ISSN：

关键词： 4-azasteroidal derivatives antiproliferative activity hydrazone synthesis

摘要：

A new series of 4-azasteroidal-17-hydrazone derivatives have been synthesized from androstenedione. Their structures were characterized by analysis and spectroscopic data. The antiproliferative activity of synthesized compounds against three cancer cells (human lung adenocarcinoma, human oesophageal cervical cancer, human gastric adenocarcinoma) and a normal cell line (human gastric mucosal) was investigated. The studies show that the compound bearing a naphthyl group displayed the same antiproliferative activity in vitro against tested cells as cis-platin did (a positive control). Most of the compounds show very weak toxicity towards normal human gastric mucosal cell line.

基金：

语种：

被引次数：

WOS：

中科院分区：

出版当年[2019]版：

大类 | 4 区化学

小类 | 4 区化学综合

最新[2025]版：

大类 | 4 区化学

小类 | 4 区化学：综合

JCR分区：

出版当年[2019]版：

Q4 CHEMISTRY, MULTIDISCIPLINARY

最新[2024]版：

Q3 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 1.2 最新[2024版] 1.3 最新五年平均 0.593 出版当年[2019版] 0.578 出版当年五年平均 0.67 出版前一年[2018版] 0.782 出版后一年[2020版]

第一作者：

第一作者机构： [1]College of Science, Hebei University of Science and Technology, Shijiazhuang, P.R. China [*1]College of Science, Hebei University of Science and Technology, Shijiazhuang 050018, Hebei, P.R. China.

通讯作者：

通讯机构： [1]College of Science, Hebei University of Science and Technology, Shijiazhuang, P.R. China [2]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China [*1]College of Science, Hebei University of Science and Technology, Shijiazhuang 050018, Hebei, P.R. China. [*2]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, P.R. China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Synthesis and biological evaluation of hydrazone and pyrazoline derivatives derived from androstenedione [2]Antiproliferative activity and toxicity of 2-methoxyestradiol in cervical cancer xenograft mice [3]Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of HeLa cervical cancer cells [4]Effects of the mitoxantrone thermosensitive liposome nanodelivery system on prostate cancer in vivo and in vitro [5]5-氨基吡唑衍生物的合成研究 [6]In Situ Ligand Synthesis Afforded Two New Metal-Organic Compounds: Luminescent and Photocatalytic Properties [7]Synthesis of a novel(99m)Tc labeled GE11 peptide for EGFR SPECT imaging [8]未成年人安宁疗护照顾者照护体验质性研究的Meta整合 [9]Secreted frizzled-related protein 5 (SFRP5) inhibits the melanin synthesis of melanocytes via Wnt/beta-catenin signaling pathway in vitiligo [10]Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells.