Rheumatoid arthritis (RA) is chronic inflammatory synovitis characterized by oxidative damage that associated with joint deformities and joint dysfunction. Single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) region of peripheral blood mitochondrial DNA (mtDNA) were sequenced in RA patients to evaluate the predictive value for RA in a case-control study. SNPs of nucleotides 146T/C, 150C/T, 195T/C, 16260C/T, and 16519T/C were found to be closely related to RA risk at statistical levels (p < 0.05). The major alleles of nucleotides 195T/C, 16260C/T and 16519C/T, the minor alleles of nucleotides 146T/C and 150C/T were associated with increased risk for RA. In conclusion, The SNPs of mtDNA D-Ioop may play roles in pathogenesis of RA.
基金：
Science and Technology Project of Hebei [162777114D]
第一作者机构：[1]Hebei Med Univ, Hosp 4, Dept Rheumatol, 12 Jiankang Rd, Shijiazhuang, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Xiaoyun,Gao Xueqing,Li Shang,et al.Identification of SNPs in displacement loop region of mitochondrial DNA as risk factors for rheumatoid arthritis[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2019,12(6):7783-7787.
APA：
Zhang, Xiaoyun,Gao, Xueqing,Li, Shang,Peng, Chenxing,Guo, Zhanjun...&Wu, Jianhua.(2019).Identification of SNPs in displacement loop region of mitochondrial DNA as risk factors for rheumatoid arthritis.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,12,(6)
MLA：
Zhang, Xiaoyun,et al."Identification of SNPs in displacement loop region of mitochondrial DNA as risk factors for rheumatoid arthritis".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 12..6(2019):7783-7787
