机构：[1]Research Center, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China河北医科大学第四医院[2]Tumor Research Institute, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China河北医科大学第四医院
The melanoma antigen gene (MAGE) proteins are a group of highly conserved family members that contain a common MAGE homology domain. Type I MAGEs are relevant cancer-testis antigens (CTAs), and originally considered as attractive targets for cancer immunotherapy due to their typically high expression in tumor tissues but restricted expression in normal adult tissues. Here, we reviewed the recent discoveries and ideas that illustrate the biological functions of MAGE family in cancer progression. Furthermore, we also highlighted the current understanding of the epigenetic mechanism of MAGE family expression in human cancers.
基金：
Nature Science Foundation of Hebei Province
(no. 2016206410).
第一作者机构：[1]Research Center, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Research Center, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050017, Hebei, People’s Republic of China
推荐引用方式(GB/T 7714)：
Lian Yishui,Meng Lingjiao,Ding Pingan,et al.Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs[J].CLINICAL EPIGENETICS.2018,10:doi:10.1186/s13148-018-0550-8.
APA：
Lian, Yishui,Meng, Lingjiao,Ding, Pingan&Sang, Meixiang.(2018).Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs.CLINICAL EPIGENETICS,10,
MLA：
Lian, Yishui,et al."Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs".CLINICAL EPIGENETICS 10.(2018)
