机构：[1]Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang,Hebei 050011医技科室放射科河北医科大学第四医院[2]Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang,Hebei 050200[3]Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017[4]Department of Pathology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China
The present study investigated the effects and potential mechanisms of action of magnesium isoglycyrrhizinate (MgIG) in doxorubicin (DOX)-treated mice. Histopathological analysis and western blot analysis were conducted in the liver and heart tissues and biochemical analysis of the serum was performed. The results revealed that MgIG (10, 20 and 40 mg/kg/day) could protect the structure and functions of the liver and heart by inhibiting the activities of the myocardial enzymes creatine kinase (CK), CK-MB and lactate dehydrogenase and the hepatic-specific enzymes aspirate aminotransferase and alanine aminotransferase, increasing the activities of the antioxidants superoxide dismutase and glutathione peroxidase, and inhibiting cellular apoptosis induced by DOX (30 mg/kg). These results demonstrate that inhibiting lipid peroxidation and reducing myocardial and hepatocyte apoptosis may be one of the mechanisms by which MgIG exhibits hepatoprotective and cardioprotective effects in DOX-treated mice.
基金：
National Natural Science Foundation of China (grant no. 81573669) and the Heibei Province Key Research Project of Medical Science of 2016 of Health and Family Planning Commission of Hebei (grant no. 20160181).
第一作者机构：[1]Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang,Hebei 050011
通讯作者：
通讯机构：[2]Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang,Hebei 050200[3]Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017[*1]Department of Pharmacology, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang, Hebei 050017, P.R. China
推荐引用方式(GB/T 7714)：
Wu Zhonglin,Zhang Yuanyuan,Song Tao,et al.Magnesium isoglycyrrhizinate ameliorates doxorubicin-induced acute cardiac and hepatic toxicity via anti-oxidant and anti-apoptotic mechanisms in mice[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2018,15(1):1005-1012.doi:10.3892/etm.2017.5470.
APA：
Wu, Zhonglin,Zhang, Yuanyuan,Song, Tao,Song, Qiongtao,Zhang, Ying...&Chu, Li.(2018).Magnesium isoglycyrrhizinate ameliorates doxorubicin-induced acute cardiac and hepatic toxicity via anti-oxidant and anti-apoptotic mechanisms in mice.EXPERIMENTAL AND THERAPEUTIC MEDICINE,15,(1)
MLA：
Wu, Zhonglin,et al."Magnesium isoglycyrrhizinate ameliorates doxorubicin-induced acute cardiac and hepatic toxicity via anti-oxidant and anti-apoptotic mechanisms in mice".EXPERIMENTAL AND THERAPEUTIC MEDICINE 15..1(2018):1005-1012
