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New Findings on the Effects of Tannic Acid: Inhibition of L-Type Calcium Channels, Calcium Transient and Contractility in Rat Ventricular Myocytes

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机构: [1]Hebei Med Univ, 361 East Zhongshan Rd, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Hosp 4, Shijiazhuang 050011, Hebei, Peoples R China [3]Hebei Univ Chinese Med, Dept Pharmacol, Shijiazhuang 050200, Hebei, Peoples R China [4]Hebei Univ Chinese Med, Dept Med Chem, Shijiazhuang 050200, Hebei, Peoples R China [5]Hebei Gen Hosp, Dept Infect Dis, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R China
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关键词: Tannic acid cardiomyocyte Ca2+ channel myocyte shortening Ca2+ transient

摘要:
Tannic acid (TA) is a group of water-soluble polyphenolic compounds that occur mainly in plant-derived feeds, food grains and fruits. Many studies have explored its biomedical properties, such as anticancer, antibacterial, antimutagenic, antioxidant, antidiabetic, antiinflammatory and antihypertensive activities. However, the effects of TA on the L-type Ca2+ current (ICa-L) of cardiomyocytes remain undefined. The present study examined the effects of TA on ICa-L using the whole-cell patch-clamp technique and on intracellular Ca2+ handling and cell contractility in rat ventricular myocytes with the aid of a video-based edge detection system. Exposure to TA resulted in a concentration- and voltage-dependent blockade of ICa-L, with the half maximal inhibitory concentration of 1.69M and the maximal inhibitory effect of 46.15%. Moreover, TA significantly inhibited the amplitude of myocyte shortening and peak value of Ca2+ transient and increased the time to 10% of the peak. These findings provide new experimental evidence for the cellular mechanism of action of TA and may help to expand clinical treatments for cardiovascular disease. Copyright (c) 2016 John Wiley & Sons, Ltd.

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出版当年[2016]版:
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 药物化学 2 区 药学
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出版当年[2016]版:
Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY
最新[2024]版:
Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY

影响因子: 最新[2024版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Hebei Med Univ, 361 East Zhongshan Rd, Shijiazhuang 050017, Hebei, Peoples R China
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通讯机构: [1]Hebei Med Univ, 361 East Zhongshan Rd, Shijiazhuang 050017, Hebei, Peoples R China [3]Hebei Univ Chinese Med, Dept Pharmacol, Shijiazhuang 050200, Hebei, Peoples R China [*1]Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China
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