机构：[1]Experimental Animal Center The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China医技科室实验动物中心河北医科大学第四医院[2]Department of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China临床科室消化内科河北医科大学第四医院
In the present study, two oxidative stress parameters, reactive oxygen species (ROS) and mitochondrial respiratory complex II, were evaluated in the mitochondria of hepatocellular carcinoma (HCC) cells to determine the association between these parameters and the carcinogenesis and clinical outcome of HCC. High levels of ROS and low levels of complex II were found to be associated with reduced post-operative survival in HCC patients using the log-rank test. Furthermore, multivariate analysis confirmed that the levels of ROS [relative risk (RR)=2.867; 95% confidence interval (CI), 1.062-7.737; P=0.038] and complex II (RR=5.422; 95% CI, 1.273-23.088; P=0.022) were independent predictors for the survival of patients with HCC. Therefore, the analysis of ROS and complex II levels may provide a useful research and therapeutic tool for the prediction of HCC prognosis and treatment.
第一作者机构：[1]Experimental Animal Center The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
通讯作者：
通讯机构：[2]Department of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China[*1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Wu Jianhua,Zhao Fei,Zhao Yufei,et al.Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma[J].ONCOLOGY LETTERS.2015,10(4):2347-2350.doi:10.3892/ol.2015.3621.
APA：
Wu, Jianhua,Zhao, Fei,Zhao, Yufei&Guo, Zhanjun.(2015).Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma.ONCOLOGY LETTERS,10,(4)
MLA：
Wu, Jianhua,et al."Mitochondrial reactive oxygen species and complex II levels are associated with the outcome of hepatocellular carcinoma".ONCOLOGY LETTERS 10..4(2015):2347-2350
