机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University临床科室消化内科河北医科大学第四医院[2]Departments of Pathology,The Fourth Hospital of Hebei Medical University河北医科大学第四医院病理科医技科室[3]Departments of Gynecology Ultrasound, The Fourth Hospital of Hebei Medical University河北医科大学第四医院[4]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA by oxidative stress. We analyzed the association of 8-OHdG with post-operative survival and revealed that low levels of 8-OHdG are associated with significantly shorter survival time. Moreover, levels of 8-OHdG were associated with HCC characteristics, including tumor size, tumor quantity, clinical staging, Child classification, portal vein thrombosis and ascites. These results suggest that oxidative damage is a useful prognostic marker in HCC when other clinical characteristics are present with 8-OHdG.
基金：
National Natural Science
Foundation of China (no. 30801384). The study was supported
in part by the Natural Science Foundation of Hebei Province
(no. C2008000958).
第一作者机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University
通讯作者：
通讯机构：[1]Departments of Gastroenterology and Hepatology,The Fourth Hospital of Hebei Medical University[4]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China[*1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, P.R. China
