Esophageal cancer is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA. We analyzed the predictive value of 8-OHdG expression on postoperative survival of patients with esophageal cancer with univariate and multivariate analysis. The high levels of 8-OHdG are associated with significantly shorter survival time by log-rank test using Kaplan-Meier methods. Moreover, the level of 8-OHdG expression was identified as an independent predictor for esophageal cancer outcome using Cox proportional hazards model analysis (relative risk, 0294; 95% confidence interval, 0.178-0.487; P = .000). These results suggest that oxidative damage marker of 8-OHdG is a useful prognostic marker in esophageal cancer. The analysis of 8-OHdG levels can help in the identification of patient subgroups that are at high risk for poor disease outcomes (C) 2014 Elsevier Inc. All rights reserved.
第一作者机构：[1]Department of Gastroenterology and Hepatology, Shijiazhuang, PR China
通讯作者：
通讯机构：[2]Department of Gynecology Ultrasound, Shijiazhuang, PR China[*1]Department of Gynecology Ultrasound, The Fourth Hospital of HebeiMedical University, 12 Jiankang Road, Shijiazhuang 050011, PR China
推荐引用方式(GB/T 7714)：
He Hongtao,Zhao Yufei,Wang Na,et al.8-Hydroxy-2 '-deoxyguanosine expression predicts outcome of esophageal cancer[J].ANNALS OF DIAGNOSTIC PATHOLOGY.2014,18(6):326-328.doi:10.1016/j.anndiagpath.2014.08.008.
APA：
He, Hongtao,Zhao, Yufei,Wang, Na,Zhang, Lan&Wang, Cuiju.(2014).8-Hydroxy-2 '-deoxyguanosine expression predicts outcome of esophageal cancer.ANNALS OF DIAGNOSTIC PATHOLOGY,18,(6)
MLA：
He, Hongtao,et al."8-Hydroxy-2 '-deoxyguanosine expression predicts outcome of esophageal cancer".ANNALS OF DIAGNOSTIC PATHOLOGY 18..6(2014):326-328
