The accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) is related to gastric carcinogenesis. To evaluate the potential relationships between DNA damage and D-loop SNPs, we measured the 8-hydroxy-2'deoxyguanosine (8-OHdG) levels in the gastric cancer tissue by immmunostaining. Our data showed that the gastric cancer susceptibility SNP of 16519C was associated with higher 8-OHdG levels. Taken together, the cancer-risk associated D-loop SNPs might initiate carcinogenesis through increasing oxidative damage.
基金：
Key Basic Research Program of Hebei Province [grant number
14967713D]; Natural Science Foundation of Hebei Province
[grant number H2015206461].
第一作者机构：[1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Yingnan,Zhao Yufei,Zhao Yue,et al.Cancer risk associated single nucleotide polymorphisms of mitochondrial D-loop and 8-hydroxy-2'-deoxyguanosine levels in gastric cancer[J].BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT.2017,31(2):363-366.doi:10.1080/13102818.2016.1270173.
APA：
Wang, Yingnan,Zhao, Yufei,Zhao, Yue,Luo, Xiaoxu,Guo, Zhanjun&Zhang, Ruixing.(2017).Cancer risk associated single nucleotide polymorphisms of mitochondrial D-loop and 8-hydroxy-2'-deoxyguanosine levels in gastric cancer.BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,31,(2)
MLA：
Wang, Yingnan,et al."Cancer risk associated single nucleotide polymorphisms of mitochondrial D-loop and 8-hydroxy-2'-deoxyguanosine levels in gastric cancer".BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 31..2(2017):363-366
