Single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with the risk and outcome in many cancers. We have identified risk associated D-loop SNPs for colorectal cancer previously, in the present study, we evaluate their prognostic value for postoperative survival of colorectal cancer (CRC). The minor haplotype of nucleotides 16290T and frequent haplotype of nucleotide 16298T in the hypervariable segment 1 (HV1) region of the D-loop were identified for their association with high survival rate of CRC. After adjusted with COX proportional hazard model, the nucleotide site of 16290 was identified as independent predictor for CRC (RR, 0.379; 95% CI, 0.171-0.839; p = 0.017). In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colorectal cancer outcome evaluation.
第一作者机构：[1]Hebei Med Univ, Hosp 4, Dept Gynaecol Ultrasound, Shijiazhuang, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, 12 Jiankang Rd, Shijiazhuang 050011, Peoples R China[*1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, P.R. China.
推荐引用方式(GB/T 7714)：
Wang Cuiju,Zhao Shengnan,Du Yanming,et al.Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with colorectal cancer outcome[J].MITOCHONDRIAL DNA PART A.2016,27(6):4361-4363.doi:10.3109/19401736.2015.1089502.
APA：
Wang, Cuiju,Zhao, Shengnan,Du, Yanming&Guo, Zhanjun.(2016).Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with colorectal cancer outcome.MITOCHONDRIAL DNA PART A,27,(6)
MLA：
Wang, Cuiju,et al."Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with colorectal cancer outcome".MITOCHONDRIAL DNA PART A 27..6(2016):4361-4363
