Associations between Single Nucleotide Polymorphisms in the Mitochondrial DNA D-Loop Region and Outcome of Gastroenteropancreatic Neuroendocrine Neoplasm
Accumulation of single-nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with cancer risk and disease outcome. We evaluated the predictive value of these SNPs for GEP-NEN outcome. Three SNP sites of nucleotides16257C/A, 150C/T and 151C/Tdel were identified for statistically significant prediction of postoperative survival in GEP-NEN by univariate analysis with log-rank test. In addition, the minor haplotype of nucleotides 16257A in the hypervariable segment 1(HV1) region of the D-loop was identified for their association with lower survival rate of GEP-NEN (relative risk, 3.390; 95% CI, 1.071 similar to 10.729; p=0.038) by multivariate analysis with COX hazards model. The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patient subgroups with a high risk of GEP-NEN outcome.
基金：
Key Basic Research Program of Hebei [20160620, ZL20140022]
第一作者机构：[1]Hebei Med Univ, Dept Endoscopy, Hosp 4, 12 Jian Kang Rd, Shijiazhuang 050011, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Med Univ, Dept Endoscopy, Hosp 4, 12 Jian Kang Rd, Shijiazhuang 050011, Hebei, Peoples R China[*1]Department of Endoscopy, The Fourth Hospital, Hebei Medical University, No12,Jian kang Road, Shijiazhuang 050011,Hebei Province, China
推荐引用方式(GB/T 7714)：
Er Li-Mian,Li Yong,Er Li,et al.Associations between Single Nucleotide Polymorphisms in the Mitochondrial DNA D-Loop Region and Outcome of Gastroenteropancreatic Neuroendocrine Neoplasm[J].ANNALS OF CLINICAL AND LABORATORY SCIENCE.2018,48(3):333-337.
APA：
Er, Li-Mian,Li, Yong,Er, Li,Wu, MingLi,Zheng, Xiu-li...&Yuan, Hu-Fang.(2018).Associations between Single Nucleotide Polymorphisms in the Mitochondrial DNA D-Loop Region and Outcome of Gastroenteropancreatic Neuroendocrine Neoplasm.ANNALS OF CLINICAL AND LABORATORY SCIENCE,48,(3)
MLA：
Er, Li-Mian,et al."Associations between Single Nucleotide Polymorphisms in the Mitochondrial DNA D-Loop Region and Outcome of Gastroenteropancreatic Neuroendocrine Neoplasm".ANNALS OF CLINICAL AND LABORATORY SCIENCE 48..3(2018):333-337
