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Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer

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机构： [1]Department of Gynaecology Ultrasound, The Fourth Hospital of HebeiMedical University, Shijiazhuang, People’s Republic ofChina [2]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, People’s Republic of China

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关键词： SNPs D-loop mtDNA Gastric cancer Outcome

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Accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk and disease outcome in a variety of cancers. We have identified cancer risk-associated D-loop SNPs in gastric cancer patients. In this study, we evaluated the predictive value of these SNPs for cancer outcome. Two SNP sites of nucleotides 489C/T and 523-524AC/del were identified for statistically significant prediction of postoperative survival in gastric cancer by univariate analysis with log-rank test. In addition, the mitochondrial DNA haplogroup N (489T) contributed to the good survival of gastric cancer patients compared with the mitochondrial DNA haplogroup M (489C) genotype (relative risk, 1.753; 95 % CI, 1.005-3.060; p=0.048) by multivariate analysis with COX hazards model. In conclusion, analysis of genetic polymorphisms in the mitochondrial D-loop can help identify subgroups of patients who are at a high risk of a poor disease outcome.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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Q2 ONCOLOGY

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影响因子： 0 最新[2023版] 0 最新五年平均 3.611 出版当年[2014版] 3.404 出版当年五年平均 2.84 出版前一年[2013版] 2.926 出版后一年[2015版]

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第一作者机构： [1]Department of Gynaecology Ultrasound, The Fourth Hospital of HebeiMedical University, Shijiazhuang, People’s Republic ofChina

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