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Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer

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机构： [1]Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang, Peoples R China [2]Hebei Med Univ, Hosp 4, Dept Gen Surg, 12 Jiankang Rd, Shijiazhuang 050011, Peoples R China

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关键词： Colon cancer D-Loop mtDNA SNPs

摘要：

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in a number of cancers. We investigated the colon cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well as the minor allele of 309C/C insert were significantly associated with an increased risk for colon cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colon cancer risk evaluation.

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无

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区遗传学

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出版当年[2016]版：

Q4 GENETICS & HEREDITY

最新[2024]版：

Q4 GENETICS & HEREDITY

影响因子： 0.6 最新[2024版] 1.3 最新五年平均 0.6 出版当年[2016版] 1.3 出版当年五年平均 0 出版前一年[2015版] 0.575 出版后一年[2017版]

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第一作者机构： [1]Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang, Peoples R China

通讯作者：

通讯机构： [2]Hebei Med Univ, Hosp 4, Dept Gen Surg, 12 Jiankang Rd, Shijiazhuang 050011, Peoples R China [*1]Department of General Surgery, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, PR China.

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