In recent years, miR-1246 has been identified as a transcriptional target of p53 in Down syndrome and may provide a new p53-miR-1246-DYRK1A-NFAT pathway in cancer. The present study aimed to explore the role of miR-1246 in the tumorigenesis of human hepatocellular carcinoma (HCC). We found that wild-type p53 regulated the expression of miR-1246 in HCC cell lines, and alteration of miR-1246 modulated cell proliferation, colony formation ability and apoptosis. The nuclear factor I/B (NFIB), an oncogene, was identified as a direct target gene of miR-1246 using a fluorescent reporter assay. Overexpression of NFIB abolished the regulation of cell apoptosis caused by miR-1246 in HepG2 cells. This finding suggests that miR-1246 is regulated by p53 and suppresses the growth of human HCC by targeting NFIB. Here, we propose a new p53-miR-1246-NFIB pathway in HCC.
第一作者机构：[1]Hebei Med Univ, Affiliated Hosp 4, Dept Surg, Shijiazhuang 050011, Hebei, Peoples R China[3]Hebei Univ, Affiliated Hosp, Dept Surg, Baoding, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Med Univ, Affiliated Hosp 4, Dept Surg, Shijiazhuang 050011, Hebei, Peoples R China[*1]Hebei Med Univ, Affiliated Hosp 4, Dept Surg, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Quan,Cao Li-Ye,Cheng Shu-Jie,et al.p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB[J].ONCOLOGY REPORTS.2015,33(3):1335-1341.doi:10.3892/or.2015.3715.
APA：
Zhang, Quan,Cao, Li-Ye,Cheng, Shu-Jie,Zhang, Ai-Min,Jin, Xiao-Shi&Li, Yong.(2015).p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB.ONCOLOGY REPORTS,33,(3)
MLA：
Zhang, Quan,et al."p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB".ONCOLOGY REPORTS 33..3(2015):1335-1341
