A novel 6/12-membered bicyclic taxane with a 13,17-ether bridge, named canataxpyran A, was isolated from the needles of Taxus canadensis. The structures were characterized as 7 beta,9,10 beta,20-tetracetoxy-13 beta,17-epoxy-3,8-secotaxa-3E,8E,11-triene-2 alpha,5 alpha-diol (designated as canataxpyran A, 1). This bicyclic taxane gradually decomposed in CDCl3 to give the corresponding enones, 10 beta,20-diacetoxy-13 beta,17-epoxy-4 alpha,5 alpha-dihydroxy-3,8-secotaxa-2E,7E,11-trien-9-one (canataxpyran B, 2) and 5 alpha,10 beta,20-triacetoxy-13 beta,17-epoxy-4 alpha-hydroxy-3,8-secotaxa-2E,7 E,11-trien-9-one (canataxpyran C, 3). Compound 1 is the first example of a natural 3,8-secotaxane with 13,17-oxygen bridge.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072551]; Key Projects of Science and Technology of Hebei Province [11276103D-89]; Scientific Research Foundation for the Returned Overseas Chinese Scholars of Hebei ProvinceScientific Research Foundation for the Returned Overseas Chinese Scholars [2006-02]; Scientific Research Foundation of Hebei Province [08B032, C2010000489]; Syngenta Ltd. (Hebei Medical University-Syngenta) [03]; Japan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [19580120, 22580112]; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [22580112] Funding Source: KAKEN
第一作者机构：[1]Hebei Med Univ, Dept Forens Med, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei Province, Peoples R China[2]Hebei Med Univ, Hosp 4, Dept Thorac, Shijiazhuang 050011, Hebei Province, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Dept Forens Med, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei Province, Peoples R China[3]Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei Province, Peoples R China
推荐引用方式(GB/T 7714)：
Li Yong,Zhang Man-Li,Wang Yu-Fang,et al.Canataxpyran A, a novel 3,8-secotaxane with a 13,17-ether bridge from needles of Taxus canadensis[J].HETEROCYCLIC COMMUNICATIONS.2012,18(2):57-60.doi:10.1515/hc-2012-0035.
APA：
Li, Yong,Zhang, Man-Li,Wang, Yu-Fang,Dong, Mei,Sauriol, Francoise...&Cong, Bin.(2012).Canataxpyran A, a novel 3,8-secotaxane with a 13,17-ether bridge from needles of Taxus canadensis.HETEROCYCLIC COMMUNICATIONS,18,(2)
MLA：
Li, Yong,et al."Canataxpyran A, a novel 3,8-secotaxane with a 13,17-ether bridge from needles of Taxus canadensis".HETEROCYCLIC COMMUNICATIONS 18..2(2012):57-60
