机构:[1]Department of Thoracic Surgery and Department of Pharmacy, The Fourth Hospital of Hebei Medical University, 12 Jiankang Lu, Shijiazhuang 050011, P. R. China河北医科大学第四医院胸五科临床科室[2]Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, P. R. China[3]Syngenta Jealotts Hill International Research Centre, Berkshire, UK
A series of new taxanes, 1-93, have been isolated, together with 37 known taxoids including Taxol((R)) (paclitaxel) and cephalomannine, from the Canadian yew, Taxus canadensis (Taxaceae) in the past 30 years. These new taxoids possess various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, and 6/12 ring systems and six new taxanes with four novel skeletons, i.e., a taxane with a 6/6/8/6 ring system, a taxane with a [3.3.3] propellane skeleton, three taxanes with [3.3.3][3.4.5] dipropellane sytems, as well as a novel taxane with a unique 5/5/4/6/6/6 hexacyclic skeleton, containing a unique [3.3.2] propellane, were isolated for the first time from natural sources. It should be emphasized that 13-acetyl-9-dihydrobaccatin III, a very useful starting material for the semisynthesis of Taxol((R)) and Taxotere((R)), represents the most abundant taxane in the needles of this yew tree. These findings establish the above mentioned yew tree as significantly different from the remaining species. On the other hand, some chemical modifications on the taxanes isolated from this plant were carried out.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072551, 81241101]; Key Projects of Science & Technology of Hebei Province [11276103D-89]; Syngenta Ltd.; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [19580120] Funding Source: KAKEN
第一作者机构:[1]Department of Thoracic Surgery and Department of Pharmacy, The Fourth Hospital of Hebei Medical University, 12 Jiankang Lu, Shijiazhuang 050011, P. R. China
通讯作者:
推荐引用方式(GB/T 7714):
Li Yong,Qin Fang,Wang Si-Ming,et al.Chemical Studies on Taxus canadensis[J].CHEMISTRY & BIODIVERSITY.2013,10(10):1729-1753.doi:10.1002/cbdv.201200032.