高级检索
当前位置: 首页 > 详情页

Chemical Studies on Taxus canadensis

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Department of Thoracic Surgery and Department of Pharmacy, The Fourth Hospital of Hebei Medical University, 12 Jiankang Lu, Shijiazhuang 050011, P. R. China [2]Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, P. R. China [3]Syngenta Jealotts Hill International Research Centre, Berkshire, UK
出处:
ISSN:

关键词: Taxus canadensis Taxanes Propellanes Yew Microtubule polymerization Taxol Diterpenoids Semisynthesis

摘要:
A series of new taxanes, 1-93, have been isolated, together with 37 known taxoids including Taxol((R)) (paclitaxel) and cephalomannine, from the Canadian yew, Taxus canadensis (Taxaceae) in the past 30 years. These new taxoids possess various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, and 6/12 ring systems and six new taxanes with four novel skeletons, i.e., a taxane with a 6/6/8/6 ring system, a taxane with a [3.3.3] propellane skeleton, three taxanes with [3.3.3][3.4.5] dipropellane sytems, as well as a novel taxane with a unique 5/5/4/6/6/6 hexacyclic skeleton, containing a unique [3.3.2] propellane, were isolated for the first time from natural sources. It should be emphasized that 13-acetyl-9-dihydrobaccatin III, a very useful starting material for the semisynthesis of Taxol((R)) and Taxotere((R)), represents the most abundant taxane in the needles of this yew tree. These findings establish the above mentioned yew tree as significantly different from the remaining species. On the other hand, some chemical modifications on the taxanes isolated from this plant were carried out.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院分区:
出版当年[2013]版:
大类 | 4 区 环境科学与生态学
小类 | 4 区 生化与分子生物学 4 区 化学综合
最新[2025]版:
大类 | 3 区 化学
小类 | 3 区 化学:综合 4 区 生化与分子生物学
JCR分区:
出版当年[2013]版:
Q2 CHEMISTRY, MULTIDISCIPLINARY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2024]版:
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CHEMISTRY, MULTIDISCIPLINARY

影响因子: 最新[2024版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者:
第一作者机构: [1]Department of Thoracic Surgery and Department of Pharmacy, The Fourth Hospital of Hebei Medical University, 12 Jiankang Lu, Shijiazhuang 050011, P. R. China
通讯作者:
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:42313 今日访问量:0 总访问量:1365 更新日期:2025-08-01 建议使用谷歌、火狐浏览器 常见问题

技术支持:重庆聚合科技有限公司 地址:河北省石家庄市健康路12号