机构：[1]Tumor Institute, No.4 Hospital of Hebei Medical University, Shijiazhuang, China[2]Research Center, No.4 Hospital of Hebei Medical University, Shijiazhuang, China[3]College of life Science, Hebei Normal University, Shijiazhuang, China
Background: The venom of spiders may inspire new drugs to treat carcinoma. The aim of this study was to investigate the effect of P38 MAPK on tumor necrosis factor-related apoptosis of lung adenocarcinoma cell line by spider venom. Methods: Lung adenocarcinoma A549 cells were cultured in PRMI-1640 medium and the apoptosis rate was observed after treatment with spider venom with a flow cytometer. The expression of P38 MAPK protein in lung cancer cells was analyzed using Western blot. Results: After targeting spider venom intervention, the expression of P38 MAPK in the cells compared to the control group was significantly down-regulated. The anticancer potency of spider venom is associated with decreased expression of P38 MAPK of lung adenocarcinoma cancer cells.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30873107]; Nature Science Foundation of Hebei ProvinceNatural Science Foundation of Hebei Province [C2007000252]; Doctor Foundation of Hebei Normal University [L2005B25]
第一作者机构：[1]Tumor Institute, No.4 Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者：
通讯机构：[3]College of life Science, Hebei Normal University, Shijiazhuang, China[*1]College of life Science, Hebei Normal University, Shijiazhuang, 050016 China.
推荐引用方式(GB/T 7714)：
Guo Jianwen,Zuo Lianfu,Liu Jianghui,et al.Effect of P38 MAPK on the apoptosis of human lung adenocarcinoma cell induced by the spider venom[J].THORACIC CANCER.2010,1(2):77-82.doi:10.1111/j.1759-7714.2010.00009.x.
APA：
Guo, Jianwen,Zuo, Lianfu,Liu, Jianghui,Hu, Xiaodong,Li, Chunyun...&Gao, Li.(2010).Effect of P38 MAPK on the apoptosis of human lung adenocarcinoma cell induced by the spider venom.THORACIC CANCER,1,(2)
MLA：
Guo, Jianwen,et al."Effect of P38 MAPK on the apoptosis of human lung adenocarcinoma cell induced by the spider venom".THORACIC CANCER 1..2(2010):77-82
