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Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases.

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收录情况： ◇ SCIE

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机构： [1]First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan. [2]Department of Immuno-oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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关键词： T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases

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T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区免疫学 2 区医学：研究与实验

最新[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学 3 区医学：研究与实验

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出版当年[2021]版：

Q1 IMMUNOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2024]版：

Q1 IMMUNOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 6.6 最新[2024版] 7 最新五年平均 10.426 出版当年[2021版] 8.388 出版当年五年平均 7.354 出版前一年[2020版] 8.1 出版后一年[2022版]

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第一作者机构： [1]First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu, 807-8555, Japan. [2]Department of Immuno-oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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