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Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis and inflammatory response by miR-195-5p/TLR4 axis through NF-κB pathway in MRC-5 cells.

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收录情况： ◇ SCIE ◇ EI

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机构： [1]Department of Pediatrics, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. [2]Department of Respiratory, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

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关键词： Circ_0038467 miR-195-5p TLR4 LPS IP

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Infantile pneumonia (IP) is an acute lower respiratory infection and brings a heavy burden to children health. Circular RNAs (circRNAs) participate in the regulation of pneumonia process. In this research, the effects of circ_0038467 in regulating lipopolysaccharide (LPS)-induced cell injury and underlying mechanism were revealed. Results showed that circ_0038467 expression and TLR4 protein level were upregulated, while miR-195-5p expression was downregulated in LPS-induced MRC-5 cells. Circ_0038467 silencing restored LPS-mediated inhibition on cell proliferation and promotion on apoptosis and inflammatory response. Additionally, circ_0038467 acted as a sponge of miR-195-5p, which was further revealed to target TLR4. MiR-195-5p inhibitor reversed circ_0038467 silencing-mediated influences under LPS treatment. Furthermore, LPS-activated NF-κB pathway was partly blocked by circ_0038467 silencing, which was restrained by TLR4 overexpression. Circ_0038467 silencing protected MRC-5 cells from LPS-induced injury by miR-195-5p/TLR4 axis through NF-κB pathway, providing a theoretical basis for circRNA-directed IP therapy. © The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.

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出版当年[2021]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学 4 区生物工程与应用微生物 4 区应用化学 4 区食品科技

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物工程与应用微生物 4 区应用化学 4 区食品科技

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出版当年[2021]版：

Q3 CHEMISTRY, APPLIED Q3 FOOD SCIENCE & TECHNOLOGY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 FOOD SCIENCE & TECHNOLOGY

影响因子： 1.4 最新[2023版] 1.9 最新五年平均 2.337 出版当年[2021版] 2.302 出版当年五年平均 2.043 出版前一年[2020版] 1.6 出版后一年[2022版]

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第一作者机构： [1]Department of Pediatrics, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

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Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis and inflammatory response by miR-195-5p/TLR4 axis through NF-κB pathway in MRC-5 cells.

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