This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 and clinical features in Chinese patients diagnosed with non-Hodgkin's lymphoma. The 9-bp GGGGGTAGA insertion/deletion in the non-d-loop area of the mitochondrial DNA at the 8272 locus was detected by PCR in 139 non-Hodgkin's lymphoma patient samples. GGGGGTAGA insertion/deletion was found in a total of 16 cases (11.5%), including nine T cell lymphoma and seven B cell lymphoma cases. The 5-year survival rate was 33.3% in patients with non-Hodgkin's lymphoma and MSI, and was 26.7% in non-Hodgkin's lymphoma patients lacking MSI. In B-cell lymphoma, the 5-year survival rate was 42.9% in patients harboring the 9-bp insertion/deletion, and was 36.8% in patients lacking MSI. In T-cell lymphoma, the 5-year survival rate was 55.6% in patients with the 9-bp insertion/deletion, and was 16.4% in patients lacking MSI (p < 0.05). The difference between 5-year survival rates was statistically significant only in T-cell lymphoma patients. In conclusion, the mtDNA GGGGGTAGA indel/variation at position 8272 can be used as an independent prognostic marker for T-cell lymphoma.
第一作者机构：[1]Hematology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Xiaolin,Diao Lanping,Zhao Guimin,et al.The mtDNA Microsatellite Instability Indicated the Prognosis of Chinese Patients with Non-Hodgkin's Lymphoma[J].ONCOLOGIE.2021,23(1):141-148.doi:10.32604/Oncologie.2021.014790.
APA：
Wu, Xiaolin,Diao, Lanping,Zhao, Guimin,Huang, Chen,Yao, Yingzhen...&Wu, Lili.(2021).The mtDNA Microsatellite Instability Indicated the Prognosis of Chinese Patients with Non-Hodgkin's Lymphoma.ONCOLOGIE,23,(1)
MLA：
Wu, Xiaolin,et al."The mtDNA Microsatellite Instability Indicated the Prognosis of Chinese Patients with Non-Hodgkin's Lymphoma".ONCOLOGIE 23..1(2021):141-148
