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Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice.

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收录情况： ◇ SCIE

作者：
Wang Xinhao[1,2] * ; Zhao Yize[1,2] * ; Shi Xiaorui[1,2] ; Gong Miao[1,2] ; Hao Ying[1,2] ; Fu Yaling[1,2] ; Velez de-la-Paz Omar Israel[1,2] ; Wang Xi[1,2] ; Du Yuru[1,2] ; Guo Xiangfei[1,2] ; Song Li[1,2,3] ; Meng Li[1,2] ; Gao Yuan[1,2,3] ; Yin Xi[1,4] ; Wang Sheng[1,2] ; Shi Yun[1,3,*1] ; Shi Haishui[1,2,*1] ;
机构： [1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [2]Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, Shijiazhuang, 050017, China [3]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, China [4]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China
出处：
DOI： 10.1016/j.ejphar.2021.174658
ISSN：

关键词： Sulfur dioxide Contextual fear memory Consolidation Reconsolidation Hippocampus

摘要：
Post-traumatic stress disorder (PTSD) is characterized by an enhancement of traumatic memory. Intervention strategies based on the different stages of memory have been shown to be effective in the prevention and control of PTSD. The endogenous gaseous molecule, sulfur dioxide (SO2), has been reported to significantly exert neuromodulatory effects; however, its regulation of learning and memory remains unestablished. This study aimed to investigate the effects of exogenous SO2 derivatives administration on the formation, consolidation, reconsolidation, retention, and expression of contextual fear memory. Behavioral results showed that both intraperitoneal injection (50 mg/kg, ip) and hippocampal infusion (5 μg/side) of SO2 derivatives (a mixture of sodium sulfite and sodium bisulfite, Na2SO3/NaHSO3, 3:1 M/M) significantly impaired consolidation but had no effect on reconsolidation and retention of contextual fear memory. These findings suggest that the attenuating effects of SO2 on the consolidation of fear memory involves, at least partially, the region of the hippocampus. The findings of this study provide direct evidence for the development of new strategies for PTSD prevention and treatment involving the use of gaseous SO2.Copyright © 2021 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (82171536 and 81800742), Natural Science Foundation of Hebei Province (H2018206119, SLRC2019047, H2020206523), Innovative Research Group Project of Hebei Province Natural Science Foundation (H2021206203).
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外文
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中科院分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 药学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [2]Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, Shijiazhuang, 050017, China
共同第一作者：
通讯作者：
通讯机构： [1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [2]Hebei Key Laboratory of Neurophysiology, Hebei Medicinal University, Shijiazhuang, 050017, China [3]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, China [*1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China.
推荐引用方式(GB/T 7714)：
Wang Xinhao,Zhao Yize,Shi Xiaorui,et al.Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice.[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2022,914:doi:10.1016/j.ejphar.2021.174658.
APA：
Wang Xinhao,Zhao Yize,Shi Xiaorui,Gong Miao,Hao Ying...&Shi Haishui.(2022).Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice..EUROPEAN JOURNAL OF PHARMACOLOGY,914,
MLA：
Wang Xinhao,et al."Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice.".EUROPEAN JOURNAL OF PHARMACOLOGY 914.(2022)

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