机构：[1]Thoracic Surgery Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China河北医科大学第四医院胸二科临床科室[2]Thoracic Surgery Department, Handan Central Hospital, Handan, China[3]Thoracic Surgery Department, Xingtai People’s Hospital, Xingtai, China[4]General Surgery Department, Xi’an Aerospace General Hospital, Xi’an, China[5]Anesthesiology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China河北医科大学第四医院麻醉三科临床科室[6]Dermatology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China临床科室皮肤科河北医科大学第四医院
Esophageal carcinoma (EC) is a common gastrointestinal malignancy that poses a threat to public health worldwide. Long noncoding RNA (lncRNA) bladder cancer-associated transcript 1 (BLACAT1) exerts a tumorigenic role in several malignant tumors; nevertheless, its function in EC remains largely unknown. Besides, programmed cell death-ligand 1 (PD-L1), an oncogene in numerous human cancers, has been identified as a therapeutic target for EC. Therefore, we intended to explore the potential regulatory network involving BLACAT1 and PD-L1 in EC. In this study, we observed increased BLACAT1 and PD-L1 levels in EC tissues and EC cell lines. Moreover, YY1 could activate BLACAT1 transcription in EC cells (TE-1 and EC9706). In addition, in vitro and in vivo experiments demonstrated that BLACAT1 facilitated EC cell proliferation and metastasis and EC tumor growth. Also, the effects of BLACAT1 silencing on EC cell functions were partially reversed by PD-L1 overexpression. Besides, it was identified that BLACAT1 competed with PD-L1 to bind to miR-5590-3p in EC cells. Furthermore, miR-5590-3p suppression could abrogate the functional effects of BLACAT1 knockdown on EC cells; while PD-L1 silencing partly abolished the promoting effects of miR-5590-3p suppression on the biological functions of EC cells. To sum up, YY1-induced BLACAT1 accelerated EC progression via regulating the miR-5590-3p/PD-L1 axis.
第一作者机构：[1]Thoracic Surgery Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者：
通讯机构：[6]Dermatology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China[*1]Dermatology Department, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang, Hebei Province, China
推荐引用方式(GB/T 7714)：
Cheng Jingge,Yang Qian,Han Xia,et al.Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway[J].BIOENGINEERED.2022,13(4):10244-10257.doi:10.1080/21655979.2022.2061303.
APA：
Cheng, Jingge,Yang, Qian,Han, Xia,Wang, Haotian,Wu, Kun&Zhao, Hongye.(2022).Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway.BIOENGINEERED,13,(4)
MLA：
Cheng, Jingge,et al."Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway".BIOENGINEERED 13..4(2022):10244-10257
