机构：[1]School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, 050200 Hebei, China[2]The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011 Hebei, China河北医科大学第四医院[3]Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, 050011 Hebei, China[4]Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Hebei University of Chinese Medicine, Shijiazhuang, 050200 Hebei, China[5]Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser hospital), Qingdao, 266000 Shandong, China
Objectives Gingerols are bioactive compounds derived from ginger, our experiment investigates the effects of 6-, 8- and 10-Gin on the human ether-a-go-go-related gene (hERG) K+ channels by using patch clamp technology. Key findings hERG K+ currents were suppressed by 6-, 8- and 10-Gin in a concentration-dependent manner. The IC50 values of 6-, 8- and 10-Gin were 41.5, 16.1 and 86.5 mu M for the hERG K+ currents, respectively. The maximum inhibitory effects caused by 6-, 8- and 10-Gin were 44.3% +/- 2.0%, 88.6% +/- 1.3% and 63.1% +/- 1.1%, respectively, and the effects were almost completely reversible. Conclusion These findings suggest that 8-Gin is the most potent hERG K+ channel inhibitor among gingerol components and may offer a new approach for understanding and treating cancer.
基金：
This study was supported by the Nature Fund of Hebei
Province (grant no. H2021423027) and the Project of Science
and Technology Research Project of Hebei Province (grant
no. BJ2020002).
第一作者机构：[1]School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, 050200 Hebei, China
共同第一作者：
通讯作者：
通讯机构：[3]Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, 050011 Hebei, China[4]Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Hebei University of Chinese Medicine, Shijiazhuang, 050200 Hebei, China[*1]Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang 050011 Hebei, China
推荐引用方式(GB/T 7714)：
Liu Miaomaio,Yang Yakun,Zhang Muqing,et al.Inhibition of human ether-a-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger[J].JOURNAL OF PHARMACY AND PHARMACOLOGY.2022,74(8):1133-1139.doi:10.1093/jpp/rgac029.
APA：
Liu, Miaomaio,Yang, Yakun,Zhang, Muqing,Xue, Yucong,Zheng, Bin...&Han, Xue.(2022).Inhibition of human ether-a-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger.JOURNAL OF PHARMACY AND PHARMACOLOGY,74,(8)
MLA：
Liu, Miaomaio,et al."Inhibition of human ether-a-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger".JOURNAL OF PHARMACY AND PHARMACOLOGY 74..8(2022):1133-1139
