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Salvia miltiorrhiza (Danshen) inhibits L-type calcium current and attenuates calcium transient and contractility in rat ventricular myocytes

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机构: [1]Hebei MedicalUniversity,361EastZhongshanRoad,Shijiazhuang050017,Hebei,China [2]Department ofPharmacology,HebeiUniversityofChineseMedicine,Shijiazhuang050200,Hebei,China [3]Department ofBasicTheoryofTraditionalChineseMedicine,HebeiUniversityofChineseMedicine,Shijiazhuang050200,Hebei,China [4]The FourthHospitalofHebeiMedicalUniversity,Shijiazhuang050011,Hebei,China
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关键词: SM Patch clamp L-type calcium current Calcium transient Myocyte contractility

摘要:
Ethnopharmacological relevance: Salvia miltiorrhiza (SM, Danshen), a traditional Chinese herbal drug, has been widely used for hundreds of years to treat coronary artery disease. Materials and methods: We studied the effects of SM on the L-type Ca2+ current (ICa-L) with whole-cell patch-clamp technique in rat ventricular myocytes, and its influence on Ca2+ transient and contractility using video-based edge detection and dual excitation fluorescence photomultiplier systems as well. Results: Exposure to SM solution caused a concentration- and voltage-dependent blockade of ICa-L, and the dose of SM solution (10 g/l) decreased the maximal inhibitory effect of 35.2 +/- 1.2%. However, SM solution did not significantly change the current voltage relationship or reversal potential of ICa-L, nor did it altered the activation and inactivation gating properties of cardiac Ca2+ channels. Meanwhile, SM decreased the amplitude of myocyte shortening and the peak value of Ca2+ transient with a significant decrease in the time to 90% of the baseline (T-r), but the time to 10% of the peak (T-p) was not dramatically prolonged. Conclusions: The results indicated that SM significantly inhibited L-type Ca2+ channels, decreased [Ca2+](i); and contractility in adult rat cardiac myocytes. These findings may be relevant to the cardioprotective efficacy of SM. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2014]版:
大类 | 3 区 医学
小类 | 2 区 全科医学与补充医学 3 区 药物化学 3 区 药学 3 区 植物科学
最新[2025]版:
大类 | 2 区 医学
小类 | 1 区 全科医学与补充医学 1 区 药学 2 区 药物化学 2 区 植物科学
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出版当年[2014]版:
Q1 PLANT SCIENCES Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY
最新[2024]版:
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子: 最新[2024版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Hebei MedicalUniversity,361EastZhongshanRoad,Shijiazhuang050017,Hebei,China
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通讯机构: [1]Hebei MedicalUniversity,361EastZhongshanRoad,Shijiazhuang050017,Hebei,China [2]Department ofPharmacology,HebeiUniversityofChineseMedicine,Shijiazhuang050200,Hebei,China [*1]Department of Pharmacology, Hebei Medical Uni- versity, Shijiazhuang 050017, Hebei, China.
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