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CircRNA mannosidase alpha class 1A member 2 promotes esophageal squamous cell carcinoma progression by regulating C-C chemokine ligand 5

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收录情况： ◇ SCIE

作者：
Liu, Lie[1] * ; Sang, Meixiang[1,2] ; Shi, Jian[3] ; Zheng, Yang[1] ; Meng, Lingjiao[1] ; Gu, Lina[1] ; Li, Ziyi[1] ; Liu, Fei[1] ; Bu, Jing[1] ; Duan, Xiaoyang[3] ; Zhao, Feifei[4] ; Zhang, Wentian[5] ; Shan, Baoen[1,2,*1] ;
机构： [1]Department of Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [2]Department of Tumor Research Institute, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [3]Department of Medical Oncology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [4]Department of Hematology, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [5]Department of Medical Oncology, Lingshou County Hospital of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, Hebei, 050500, People's Republic of China
出处：
DOI： 10.1016/j.bbrc.2023.01.043
ISSN：

关键词： Esophageal squamous cell carcinoma Circular RNA CCL5

摘要：
Esophageal squamous cell carcinoma (ESCC) is a common malignancy with high morbidity and mortality. Although circular RNAs (circRNAs) play important roles in various cancers including ESCC, the role of the circRNA mannosidase alpha class 1A member 2 (circMAN1A2) in ESCC has been rarely studied. This study aimed to explore the role of circMAN1A2 in ESCC. CircMAN1A2 expression in ESCC tissues and cells was evaluated, and the relationship between circMAN1A2 expression and prognosis in patients with ESCC was analyzed. C-C chemokine ligand 5 (CCL5) was found to be a downstream target of circMAN1A2 by analysing the Agilent Microarray. Next, we performed in vitro and in vivo xenotransplantation assays to explore the role of circMAN1A2 in ESCC. We observed that high circMAN1A2 expression is associated with poor prognosis in patients with ESCC. Suppression of circMAN1A2 expression inhibits the prolif-eration, migration, and invasiveness of ESCC via regulating CCL5. Our results suggest that circMAN1A2 can promote the progression of ESCC by regulating CCL5. Thus, circMAN1A2 might be a novel diagnostic biomarker of ESCC, and targeting circMAN1A2 using inhibitors could be a potential therapeutic strategy to treat ESCC. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

基金：
Financial Supporting Program of Hebei Province [[2014] 1257]

基金编号： [2014] 1257

语种：
外文
被引次数：
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中科院分区：
出版当年[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
JCR分区：
出版当年[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China
通讯作者：
通讯机构： [1]Department of Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [2]Department of Tumor Research Institute, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [*1]Department of Research Center and Tumor Research Institute, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China
推荐引用方式(GB/T 7714)：
Liu Lie,Sang Meixiang,Shi Jian,et al.CircRNA mannosidase alpha class 1A member 2 promotes esophageal squamous cell carcinoma progression by regulating C-C chemokine ligand 5[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2023,645:61-70.doi:10.1016/j.bbrc.2023.01.043.
APA：
Liu, Lie,Sang, Meixiang,Shi, Jian,Zheng, Yang,Meng, Lingjiao...&Shan, Baoen.(2023).CircRNA mannosidase alpha class 1A member 2 promotes esophageal squamous cell carcinoma progression by regulating C-C chemokine ligand 5.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,645,
MLA：
Liu, Lie,et al."CircRNA mannosidase alpha class 1A member 2 promotes esophageal squamous cell carcinoma progression by regulating C-C chemokine ligand 5".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 645.(2023):61-70

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