机构：[1]Research Center and Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China河北医科大学第四医院[2]The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China临床科室外三科河北医科大学第四医院
Autophagy is a kind of intracellular degradation pathway which could be regulated by many noncoding RNAs. ciRS-7, also called CDR1as, is a circular RNA that is relatively well studied at present. In our recent study, we have found that the expression of ciRS-7 is abnormally increased in the esophageal squamous cell carcinoma (ESCC), and may function as an oncogene to accelerate ESCC progression through sponging miR-876-5p. Meanwhile, another study showed that ciRS-7 is highly expressed in the triple-negative breast cancer (TNBC) and may function as a competing endogenous RNA of miR-1299 to maintain the high migration and invasive capacity of TNBC cells. Of interest, in the present work, we observed that ciRS-7 could inhibit starvation or rapamycin-induced autophagy of ESCC cells and miR-1299 promotes starvation or rapamycin-induced autophagy of ESCC cells. Mechanically, miR-1299 could directly bind to the 3'-untranslated region of epidermal growth factor receptor (EGFR) and then affects its downstream Akt-mTOR pathway in ESCC cells. Consistent with our past findings, ciRS-7 could also sponge miR-1299 in ESCC cells. Taken together, this study has shed light on that circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling.
基金：
Medical Science Research Foundation of
Health and Family Planning Commission
of Hebei, Grant/Award Numbers:
20190088, 20190720; Administration of
Traditional Chinese Medicine of Hebei
Province, Grant/Award Number: 2019133
第一作者机构：[1]Research Center and Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
共同第一作者：
通讯作者：
通讯机构：[1]Research Center and Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China[*1]Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017 Hebe, China.
推荐引用方式(GB/T 7714)：
Meng Lingjiao,Liu Sihua,Ding Pingan,et al.Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling[J].JOURNAL OF CELLULAR BIOCHEMISTRY.2020,121(2):1039-1049.doi:10.1002/jcb.29339.
APA：
Meng, Lingjiao,Liu, Sihua,Ding, Pingan,Chang, Sheng&Sang, Meixiang.(2020).Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling.JOURNAL OF CELLULAR BIOCHEMISTRY,121,(2)
MLA：
Meng, Lingjiao,et al."Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling".JOURNAL OF CELLULAR BIOCHEMISTRY 121..2(2020):1039-1049
