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Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression

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收录情况： ◇ SCIE

作者：
Sang, Meixiang[1,2,*1] * ; Meng, Lingjiao[1] * ; Sang, Yang[3] ; Liu, Shina[1] ; Ding, Pingan[1] ; Ju, Yingchao[1] ; Liu, Fei[1] ; Gu, Lina[1] ; Lian, Yishui[1] ; Li, Juan[1] ; Wu, Yunyan[1] ; Zhang, Xiaochong[1] ; Shan, Baoen[1,2,*1] ;
机构： [1]Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [2]Tumor Research Institute, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [3]Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
出处：
DOI： 10.1016/j.canlet.2018.03.049
ISSN：

关键词： ESCC Circular RNA ciRS-7 miR-876-5p MAGE-A

摘要：
As the most well-known circular RNA, ciRS-7 (also termed CDR1as) has been reported to act as a miR-7 sponge, resulting in reduced miR-7 activity and increased miR-7-targeted transcripts. Here, we showed that ciRS-7 is up-regulated in esophageal squamous cell carcinoma (ESCC), and is associated with the poor clinicopathological parameters of ESCC patients. Moreover, over-expression of ciRS-7 increased the proliferation, migration and invasion of ESCC cells. Mechanistic studies revealed that ciRS-7 contains nineteen miR-876-5p binding sites and acts as a miR-876-5p sponge. Over-expression of ciRS-7 resulted in the reduced tumor-repressive function of miR-876-5p on its downstream target MAGE-A family. In animal experiments, enforced ciRS-7 increased ESCC tumor growth and metastasis through targeting miR-876-5p/MAGE-A family axis. Collectively, our study provided novel evidence that ciRS-7 accelerates ESCC progression by acting as a miR-876-5p sponge to enhance MAGE-A family expression. (C) 2018 Elsevier B.V. All rights reserved.

基金：
Nature Science Foundation of Hebei Province (No. 2016206410).
语种：
外文
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中科院分区：
出版当年[2018]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q1 ONCOLOGY
最新[2024]版：
Q1 ONCOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [2]Tumor Research Institute, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [*1]Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [2]Tumor Research Institute, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China [*1]Research Center, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050017, People's Republic of China.
推荐引用方式(GB/T 7714)：
Sang Meixiang,Meng Lingjiao,Sang Yang,et al.Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression[J].CANCER LETTERS.2018,426:37-46.doi:10.1016/j.canlet.2018.03.049.
APA：
Sang, Meixiang,Meng, Lingjiao,Sang, Yang,Liu, Shina,Ding, Pingan...&Shan, Baoen.(2018).Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression.CANCER LETTERS,426,
MLA：
Sang, Meixiang,et al."Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression".CANCER LETTERS 426.(2018):37-46

相关文献

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