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Circular RNA circ-TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR-452-5p/DAG1 axis

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收录情况： ◇ SCIE

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机构： [1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China [2]The Third Department of Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China [3]Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China [4]Tumor Research Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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关键词： circ-TNRC6B circular RNA DAG1 esophageal squamous cell carcinoma miR-452-5p

摘要：

Previous studies have uncovered the key role of circular RNAs (circRNAs) in various diseases, including cancer. However, the growth-inhibitory effects of circRNAs on esophageal squamous cell carcinoma (ESCC) have not been completely elucidated. This study characterized a newly identified circRNA derived from exons 9-13 of TNRC6B (named circ-TNRC6B). The expression of circ-TNRC6B in ESCC tissues was markedly downregulated when compared to that in non-tumor tissues. In 53 ESCC cases, circ-TNRC6B expression was negatively correlated with the T stage. Multivariate Cox regression analysis showed that circ-TNRC6B upregulation was an independent protective factor for ESCC patients' prognosis. Overexpression and knockdown functional experiments demonstrated that circ-TNRC6B inhibited ESCC cell proliferation, migration, and invasion. RNA immunoprecipitation and dual-luciferase reporter assays demonstrated that circ-TNRC6B sponges oncogenic miR-452-5p to upregulate the expression and activity of DAG1. Treatment with miR-452-5p inhibitor partially reversed the circ-TNRC6B-induced changes in the biological behavior of ESCC cells. These findings demonstrated that circ-TNRC6B exerts a tumor-suppressing effect in ESCC through the miR-452-5p/DAG1 axis. Thus, circ-TNRC6B is a potential prognostic biomarker for the clinical management of ESCC.

基金：

基金编号： 82002577

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出版当年[2023]版：

大类 | 2 区

医学

小类 | 2 区肿瘤学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

JCR分区：

出版当年[2023]版：

Q1 ONCOLOGY

最新[2023]版：

Q1 ONCOLOGY

影响因子： 5 最新[2023版] 6.5 最新五年平均 5 出版当年[2023版] 6.5 出版当年五年平均 6.6 出版前一年[2022版]

第一作者：

第一作者机构： [1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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通讯作者：

通讯机构： [1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China [4]Tumor Research Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China [*1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China

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