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Identification of sequence polymorphisms in the mitochondrial cytochrome c oxidase genes as risk factors for hepatocellular carcinoma

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收录情况： ◇ SCIE

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机构： [1]College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China [2]Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [3]Department of Thoracic Surgery, Xingtai People’s Hospital, Xingtai, China [4]Department of Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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关键词： cytochrome c oxidase genes hepatocellular carcinoma mitochondrial DNA single nucleotide polymorphisms

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BackgroundSingle nucleotide polymorphisms (SNPs) accumulated in the mitochondrial DNA (mtDNA) is susceptible to the tumor formation. We discovered previously that SNPs in the mitochondrial displacement loop (D-loop) was associated with the risk of hepatocellular carcinoma (HCC). MethodsThe cytochrome c oxidase (COX) genes of mtDNA were sequenced between 107 HCC patients and 100 matched healthy controls. The (2) test was used to analyze single SNPs' statistical difference between HCC patients and healthy controls. ResultsIn this study, cancer risk-associated SNPs in the COX genes of mtDNA coding region were assessed in HCC patients and health controls. The nucleotide position at site 9545A/G (P=.036) was identified its association for HCC with the 9545G allele susceptible to cancer risk. ConclusionsThe SNPs in the COX genes may help us to evaluate the cancer risk of HCC.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区医学实验技术

最新[2025]版：

大类 | 4 区医学

小类 | 3 区医学实验技术

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出版当年[2018]版：

Q3 MEDICAL LABORATORY TECHNOLOGY

最新[2024]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 2.9 最新[2024版] 2.6 最新五年平均 1.728 出版当年[2018版] 1.604 出版当年五年平均 1.303 出版前一年[2017版] 1.54 出版后一年[2019版]

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第一作者机构： [1]College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China

通讯作者：

通讯机构： [2]Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [4]Department of Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [*1]Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. [*2]Department of Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

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