机构：[1]Departments of Molecular Biology,Hebei Medical University, Fourth Hospital, Shijiazhuang , China河北医科大学第四医院[2]Departments of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang , China河北医科大学第四医院
The loss of E-cadherin expression plays an important role in the development of endometriosis, but the molecular mechanism is not clear to date. It has been confirmed that the hypermethylation of the CpG island may be an important molecular mechanism in the transcriptional inactivation of E-cadherin gene (CDH1) in many cancers. The present study investigated the methylation status of CDH1 promoter region in ovarian endometriotic cysts and the endometrium of women with ovarian endometriosis. The results showed that the frequency of CDH1 promoter methylation in eutopic (26%), ectopic tissues (32%) of women with ovarian endometriosis was significantly higher than that of endometrium tissue of women without endometriosis (8%). Further, results of the study showed that the expression level of mRNA and protein of E-cadherin in methylation-positive tissues was significantly lower than that in methylation-negative tissues (p = 0.023 and 0.035, respectively). Pearson's correlation coefficients analysis showed the level of CDH1 mRNA expression was closely related to the level of E-cadherin protein expression. The results implied that the aberrant methylation of the CDH1 promoter region in the endometrium of the women may contribute, at least in part, to the development of ovarian endometriosis. (C) 2016 S. Karger AG, Basel
基金：
This work was supported by a grant from the National Natural
Science Foundation of China (No. 81270673).
第一作者机构：[1]Departments of Molecular Biology,Hebei Medical University, Fourth Hospital, Shijiazhuang , China
通讯作者：
通讯机构：[2]Departments of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang , China[*1]Department of Obstetrics and Gynaecology,Hebei Medical University, Fourth Hospital,Jiankanglu 12, Shijiazhuang 050011 (China)
推荐引用方式(GB/T 7714)：
Li Yan,An Dong,Guan Ying-xia,et al.Aberrant Methylation the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endotmetriosis[J].GYNECOLOGIC AND OBSTETRIC INVESTIGATION.2017,82(1):78-85.doi:10.1159/000445293.
APA：
Li, Yan,An, Dong,Guan, Ying-xia&Kang, Shan.(2017).Aberrant Methylation the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endotmetriosis.GYNECOLOGIC AND OBSTETRIC INVESTIGATION,82,(1)
MLA：
Li, Yan,et al."Aberrant Methylation the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endotmetriosis".GYNECOLOGIC AND OBSTETRIC INVESTIGATION 82..1(2017):78-85
