机构：[1]Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China医技科室分子生物学室河北医科大学第四医院[2]Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China
The genetic polymorphisms in E-cadherin gene (CDH1) may affect invasive/metastatic disease development by altering gene transcriptional activity. In this paper, we investigated the effect of 3'-UTR +54C/T polymorphism (rs1801026) in CDH1 gene on the risk and progression of several common cancers. Multiple completely independent case-control analyses of 1081 cancer patients with esophageal squamous cell carcinoma (ESCC), gastric cardiac adenocarcinoma (GCA), non-small-cell lung cancer (NSCLC), and cervical cancer and 1131 control subjects in northern Chinese populations. The results showed that the carriers with T allele were significantly decreased the risk of developing GCA, NSCLC, and cervical cancer, with an adjusted odds ratio of 0.67 (95% CI = 0.48-0.91), 0.68 (95% CI = 0.49-0.92), and 0.66 (95% CI = 0.48-0.92), respectively. There were no association between the frequency of genotype and the clinicopathological features of ESCC, GCA, and NSCLC, but the frequency of T allele was significantly lower in patients of stage III cervical cancer (P = 0.026). These results suggested that the 3'-UTR +54C/T polymorphism in CDH1 may be a marker for genetic susceptibility of cancer. (C) 2011 Wiley Periodicals, Inc.
基金：
Hebei Universities; Research and Development in Hebei Province [08276101D-41]
第一作者机构：[1]Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China[*1]Department of Molecular Biology, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, China
通讯作者：
通讯机构：[1]Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China[*1]Department of Molecular Biology, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, China
推荐引用方式(GB/T 7714)：
Li Yan,Tang Yuanjia,Zhou Rongmiao,et al.Genetic Polymorphism in the 3 '-Untranslated Region of the E-Cadherin Gene Is Associated With Risk of Different Cancers[J].MOLECULAR CARCINOGENESIS.2011,50(11):857-862.doi:10.1002/mc.20765.
APA：
Li, Yan,Tang, Yuanjia,Zhou, Rongmiao,Sun, Donglan,Duan, Yanan...&Shen, Nan.(2011).Genetic Polymorphism in the 3 '-Untranslated Region of the E-Cadherin Gene Is Associated With Risk of Different Cancers.MOLECULAR CARCINOGENESIS,50,(11)
MLA：
Li, Yan,et al."Genetic Polymorphism in the 3 '-Untranslated Region of the E-Cadherin Gene Is Associated With Risk of Different Cancers".MOLECULAR CARCINOGENESIS 50..11(2011):857-862
