详情页 - 河北医科大学第四医院机构库

当前位置：首页 > 详情页

Neuropeptide Trefoil factor 3 improves learning and retention of novel object recognition memory in mice

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China [2]Hebei Medical University Fourth Hospital, Hebei Medical University, China [3]Department of Surgery, Hebei Medical University, China

出处：

DOI：

ISSN：

关键词： Neuropeptide Trefoil factor 3 Memory Object recognition Mice

摘要：

Accumulating evidence has implicated neuropeptides in modulating recognition, learning and memory. However, to date, no study has investigated the effects of neuropeptide Trefoil factor 3 (TFF3) on the process of learning and memory. In the present study, we evaluated the acute effects of TFF3 administration (0.1 and 0.5 mg/kg, i.p.) on the acquisition and retention of object recognition memory in mice. We found that TFF3 administration significantly enhanced both short-term and long-term memory during the retention test, conducted 90 min and 24 h after training respectively. Remarkably, acute TFF3 administration transformed a learning event that would not normally result in long-term memory into an event retained for a long-term period and produced no effect on locomotor activity in mice. In conclusion, the present results provide an important role of TFF3 in improving object recognition memory and reserving it for a longer time, which suggests a potential therapeutic application for diseases with recognition and memory impairment. (C) 2011 Elsevier B.V. All rights reserved.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院分区：

出版当年[2012]版：

大类 | 3 区医学

小类 | 3 区行为科学 3 区神经科学

最新[2025]版：

大类 | 3 区心理学

小类 | 3 区行为科学 4 区神经科学

JCR分区：

出版当年[2012]版：

Q2 BEHAVIORAL SCIENCES Q2 NEUROSCIENCES

最新[2023]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子： 2.6 最新[2023版] 2.8 最新五年平均 3.327 出版当年[2012版] 3.674 出版当年五年平均 3.417 出版前一年[2011版] 3.391 出版后一年[2013版]

第一作者：

第一作者机构： [1]Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]CB2 cannabinoid receptor agonist ameliorates novel object recognition but not spatial memory in transgenic APP/PS1 mice [2]神经肽三叶因子3对可卡因奖赏效应的影响 [3]Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice. [4]Exogenous SO2 donor treatment impairs reconsolidation of drug reward memory in mice. [5]Methylene blue exerts rapid neuroprotective effects on lipopolysaccharide-induced behavioral deficits in mice [6]Corrigendum to "Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice" [Eur. J. Pharmacol. 914 2021 174658]. [7]Effects of chronic triclosan exposure on social behaviors in adult mice. [8]慢性间歇性低压低氧改善全脑照射造成的小鼠记忆认知功能障碍的研究 [9]Corrigendum to "Sulfur dioxide derivatives attenuates consolidation of contextual fear memory in mice" [Eur. J. Pharmacol. 914 2021 174658]. [10]异黄酮衍生物J39136对东莨菪碱致学习记忆障碍模型小鼠的影响