Early onset, multiple primary malignancies, and poor prognosis are indicative of an inherited predisposition to esophageal squamous cell carcinoma for the familial as opposed to the sporadic cases - An update on over 14-year survival
机构：[1]Epidemiology, Hebei Cancer Institute and The Fourth Hospital of Hebei Medical University, Jiankanglu 12, Hebei Medical University, Shijiazhuang 050011, China临床科室河北省肿瘤研究所河北医科大学第四医院[2]Department of Endoscopies, Hebei Tumor Hospital and The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China河北医科大学第四医院
Background: To demonstrate the effect of an inherited predisposition in familial Esophageal Squamous Cell Carcinoma (ESCC) as opposed to the sporadic cancer form. Methods: Differences in age of onset, prevalence rates of double primary ESCC, and post-operative survival rates between ESCC cases with (N = 476) and without (N = 1226)a family history of upper gastrointestinal cancer (FHUGIC, defined as having one or more first- or second-degree relatives with cancer of the esophagus or gastric cardia) were analyzed. Results: Overall, familial ESCC cases show a significantly earlier onset age (51.9 +/- 8.2 versus 53.4 +/- 8.0, Pt-test=.000), a significantly higher prevalence rate of double primary ESCC (2.73% Versus 1.22%, adjusted with TNM: X-MH(2) = 4.029, P = .045), and a worse prognosis than the sporadic cases (P-wald = .049). In subgroup analyses, the familial cases showed earlier onset and poor survival at most subgroups as opposed to the sporadic cases, and the difference was greater in early-stage rather than in late-stage groups (Pt-test for difference in onset age in Tis,1N0M0, T2,3N0M0, and T2,3,4N1M0 were .002, .006, and .081 respectively; and P-wald for difference in survival in Tis,1N0M0, T2,3N0M0, and in T2,3,4N1M0 were .010, .180, and .520 respectively). Conclusion: These findings suggest the existence of familial as opposed to the sporadic ESCC. By the theory of "two-hit" origin of cancer, these findings also suggest that the "first hit", a genetic predisposition, is inherited in familial ESCC. (C) 2009 Elsevier Masson SAS. All rights reserved.
基金：
11.5th Chinese Country supported program [2006BA102A0]; Program for Construction of Key Scientific Disciplines in Universities of Hebei Provinc
第一作者机构：[1]Epidemiology, Hebei Cancer Institute and The Fourth Hospital of Hebei Medical University, Jiankanglu 12, Hebei Medical University, Shijiazhuang 050011, China
通讯作者：
通讯机构：[1]Epidemiology, Hebei Cancer Institute and The Fourth Hospital of Hebei Medical University, Jiankanglu 12, Hebei Medical University, Shijiazhuang 050011, China[2]Department of Endoscopies, Hebei Tumor Hospital and The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
推荐引用方式(GB/T 7714)：
Wen Denggui,Wang Shijie,Zhang Liwei,et al.Early onset, multiple primary malignancies, and poor prognosis are indicative of an inherited predisposition to esophageal squamous cell carcinoma for the familial as opposed to the sporadic cases - An update on over 14-year survival[J].EUROPEAN JOURNAL OF MEDICAL GENETICS.2009,52(6):381-385.doi:10.1016/j.ejmg.2009.07.003.
APA：
Wen, Denggui,Wang, Shijie,Zhang, Liwei,Wei, Lizhen,Zhou, Wendi&Peng, Qing.(2009).Early onset, multiple primary malignancies, and poor prognosis are indicative of an inherited predisposition to esophageal squamous cell carcinoma for the familial as opposed to the sporadic cases - An update on over 14-year survival.EUROPEAN JOURNAL OF MEDICAL GENETICS,52,(6)
MLA：
Wen, Denggui,et al."Early onset, multiple primary malignancies, and poor prognosis are indicative of an inherited predisposition to esophageal squamous cell carcinoma for the familial as opposed to the sporadic cases - An update on over 14-year survival".EUROPEAN JOURNAL OF MEDICAL GENETICS 52..6(2009):381-385
