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Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

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WOS体系：
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收录情况： ◇ SCIE

作者：
Zhang Xiaowei[1] * ; Diao Xinpeng[2] ; Li Luya[3] ; Zhang Yuqian[1] ; Liao Man[2] ; Zhang Guohua[1,*1] ; Zhang Lantong[2,*2] ;
机构： [1]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, P. R. China [2]Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China [3]Department of Pharmacy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P. R. China
出处：
DOI： 10.1002/jssc.202101016
ISSN：

关键词： Ginkgolide B liquid chromatography mass spectrometry metabolites

摘要：
Ginkgolide B is a dietary diterpene with multiple pharmacological activities. However, current research on ginkgolide B is not comprehensive. The current study analyzed the metabolic profile of ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry. To detect and identify the different metabolites in ginkgolide B, a novel data processing method was used as an assistant tool. A total of 53 different metabolites of ginkgolide B (38 phase I metabolites and 15 phase II metabolites) were detected relative to blank samples. The biotransformation route of ginkgolide B was identified as oxidation, dehydroxylation, hydrogenation, decarbonylation, demethylation, sulfate conjugation, glucose conjugation, methylation, and acetylation. The current study demonstrated a method for rapidly detecting and identifying metabolites and provided useful information to further characterize the pharmacology and mechanism of ginkgolide B. A method for the analysis of other diterpene metabolic components in vivo and in vitro was also established.© 2022 Wiley-VCH GmbH.

基金：
the National Natural Science Foundation of China, Grant/Award Number: 81473180
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2022]版：
大类 | 3 区 工程技术
小类 | 3 区 分析化学 3 区 工程：化工
最新[2025]版：
大类 | 3 区 工程技术
小类 | 3 区 分析化学
JCR分区：
出版当年[2022]版：
Q2 CHEMISTRY, ANALYTICAL
最新[2023]版：
Q2 CHEMISTRY, ANALYTICAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, P. R. China
通讯作者：
通讯机构： [1]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, P. R. China [2]Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China [*1]Department of Neurosurgery, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Shijiazhuang, Hebei 050000, P. R. China. [*2]Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, No.361, Zhongshan East Road, Shijiazhuang, 050017, P. R. China.
推荐引用方式(GB/T 7714)：
Zhang Xiaowei,Diao Xinpeng,Li Luya,et al.Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.[J].JOURNAL OF SEPARATION SCIENCE.2022,45(14):2458-2477.doi:10.1002/jssc.202101016.
APA：
Zhang Xiaowei,Diao Xinpeng,Li Luya,Zhang Yuqian,Liao Man...&Zhang Lantong.(2022).Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry..JOURNAL OF SEPARATION SCIENCE,45,(14)
MLA：
Zhang Xiaowei,et al."Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.".JOURNAL OF SEPARATION SCIENCE 45..14(2022):2458-2477

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