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Quantification of orelabrutinib in human plasma and cerebrospinal fluid by liquid chromatography tandem mass spectrometry

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机构: [1]College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 050018 Shijiazhuang, China [2]Shijiazhuang Customs Technology Center, 050051 Shijiazhuang, China [3]College of Public Health, Hebei Medical University, 050017 Shijiazhuang, China [4]Hebei Medical University Fourth Hospital, 050000 Shijiazhuang, China
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关键词: Orelabrutinib Liquid chromatography -mass spectrometry Plasma Cerebrospinal fluid

摘要:
A sensitive and simple method was developed to determine orelabrutinib in human plasma and cerebrospinal fluid by liquid chromatography tandem mass spectrometry (LC-MS/MS). The samples were prepared by simple protein precipitation with by 0.1% formic acid acetonitrile solution and efficient separations were performed on the Thermo Hypersll GOLD C18 column (2.1 mm x 150 mm, 5 mu m) under a gradient program in a total run time of 9 min. The orelabrutinib was detected by electrospray ionization in positive ion mode with selective reaction monitoring (SRM) and mass spectrometric conditions were optimized in order to increase selectivity and sensitivity. The developed method was validated in terms of its accuracy, precision, selectivity, linearity, recovery, matrix effect, stability, and limits of quantification (LOQ). The lower limit of quantification is 0.50 ng/ mL, the intraday and interday precision RSD are both less than 15%, and the recovery rate is 85.7%-92.9%. Finally, the method was successfully applied for the quantitation of orelabrutinib in human plasma and cerebrospinal fluid of clinical patients treated with orelabrutinib.

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出版当年[2023]版:
大类 | 3 区 医学
小类 | 3 区 生化研究方法 3 区 分析化学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 生化研究方法 3 区 分析化学
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出版当年[2023]版:
Q2 BIOCHEMICAL RESEARCH METHODS Q2 CHEMISTRY, ANALYTICAL
最新[2024]版:
Q2 BIOCHEMICAL RESEARCH METHODS Q2 CHEMISTRY, ANALYTICAL

影响因子: 最新[2024版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版] 出版后一年[2024版]

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第一作者机构: [1]College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 050018 Shijiazhuang, China
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通讯机构: [4]Hebei Medical University Fourth Hospital, 050000 Shijiazhuang, China [*1]Hebei Medical University Fourth Hospital, 12 Jiankang Road, 050011 Shijiazhuang, Hebei, China.
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